Table of Contents

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

SCHEDULE 14A

(Rule 14a-101)

SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the

Securities Exchange Act of 1934

(Amendment No.   )

Filed by the Registrant  x                          Filed by a Party other than the Registrant  ¨

Check the appropriate box:

¨

Preliminary Proxy Statement

¨

Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

x

Definitive Proxy Statement

¨

Definitive Additional Materials

¨

Soliciting Material Pursuant to §240.14a-12

PASSAGE BIO, INC.

(Name of Registrant as Specified In Its Charter)

N/A

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

Payment of Filing Fee (Check the appropriate box):

xNo fee required.

¨

Fee paid previously with preliminary materials.

¨Fee computed on table belowin exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11.

1)

Title of each class of securities to which transaction applies:

2)

Aggregate number of securities to which transaction applies:

3)

Per unit price or other underlying value of transaction computed pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing fee is calculated and state how it was determined):

4)

Proposed maximum aggregate value of transaction:

5)

Total fee paid:

Fee paid previously with preliminary materials.

Check box if any part of the fee is offset as provided by Exchange Act Rule 0-11(a)(2) and identify the filing for which the offsetting fee was paid previously. Identify the previous filing by registration statement number, or the Form or Schedule and the date of its filing.

1)

Amount Previously Paid:

2)

Form, Schedule or Registration Statement No.:

3)

Filing Party:

4)

Date Filed:


Table of Contents

PASSAGE BIO, INC.


One Commerce Square


2005 Market Street, 39th39th Floor


Philadelphia, PA 19103

NOTICE OF ANNUAL MEETING OF STOCKHOLDERS


To Be Held May 27, 202121, 2024

To Our Stockholders:

NOTICE IS HEREBY GIVEN that the 20212024 Annual Meeting of Stockholders of Passage Bio, Inc. will be held via a virtual meeting due to the public health and travel concerns our stockholders may have and recommendations that public health officials have issued and may issue in light of the coronavirus (COVID-19) pandemic.meeting. You will be able to participate in the 20212024 Annual Meeting and vote during the 20212024 Annual Meeting via live webcast by visiting www.virtualshareholdermeeting.com/PASG2021PASG2024 on Thursday,Tuesday, May 27, 202121, 2024, at 4:30 p.m.9:00 a.m. Eastern Time. We believe that a virtual stockholder meeting provides greater access to those who may want to attend and therefore we have chosen this over an in-person meeting. It is important that you retain a copy of the control number found on the proxy card or voting instruction form, as such number will be required in order for stockholders to gain access to the virtual meeting.

We are holding the meeting for the following purposes, which are more fully described in the accompanying proxy statement:

1.To elect threetwo Class I directors, each to serve a three-year term through the third annual meeting of stockholders following this meeting and until a successor has been elected and qualified or until earlier resignation or removal.

2.To ratify the appointment of KPMG LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2021.2024.

In addition, stockholders may be asked to consider and vote upon such other business as may properly come before the meeting or any adjournment or postponement thereof.

Only stockholders of record at the close of business on April 5, 2021March 28, 2024, are entitled to receive notice of, and to vote at, the meeting and any adjournments thereof. On or about April 14, 2021,9, 2024, we expect to mail to stockholders a Notice of Internet Availability of Proxy Materials (the Notice of Internet Availability”)Availability) containing instructions on how to access our proxy statement for our 20212024 Annual Meeting and our 20202023 Annual Report on Form 10-K to stockholders. The Notice of Internet Availability also provides instructions on how to vote through the internet or by telephone and includes instructions on how to receive paper copies of the proxy materials by mail, if desired.

For ten days prior to the meeting, a complete list of the stockholders entitled to vote at the meeting will be available upon request by any stockholder for any purpose relating to the meeting. Stockholders can request the list of stockholders throughby contacting our investor relations websiteteam at https://investors.passagebio.com/investor-resources/‌investor- contact.investors@passagebio.com.

The stockholder list will also be available during the virtual meeting via www.virtualshareholdermeeting.com/‌PASG2021.

Your vote as a Passage Bio, Inc. stockholder is very important. Each share of common stock that you own represents one vote.

For questions regarding your stock ownership, you may contact our Corporate Secretary at ccale@passagebio.cominvestors@passagebio.com or, if you are a registered holder, our transfer agent, Computershare Trust Company, N.A. by email through their website at www.computershare.com/contactus or by phone at (800) 736- 3001736-3001. Whether or not you expect to attend the meeting, we encourage you to read the proxy statement and vote through the internet or by telephone, or to request, sign and return


Table of Contents

your proxy card as soon as possible, so that your shares may be represented at the meeting. For specific instructions on how to vote your shares, please refer to the section entitled “General Proxy Information” in the proxy statement.

By Order of the Board of Directors,

Graphic

William Chou, M.D,

Bruce Goldsmith, Ph.D.

President and Chief Executive Officer and President

Philadelphia, Pennsylvania
April 9, 2024

April 14, 2021

Important Notice Regarding the Availability of Proxy Materials for the virtual Annual Meeting of Stockholders to be held on May 27, 2021:21, 2024: the Proxy Statement and our 20202023 Annual Report on Form 10-K are available at www.ProxyVote.com. You will need the control number included on your proxy card or voting instruction form, or included in the e-mail to you if you received the proxy materials by e-mail, as such number will be required in order for stockholders to gain access to the virtual meeting.



PASSAGE BIO, INC.


One Commerce Square


2005 Market Street, 39th Floor


Philadelphia, PA 19103

PROXY STATEMENT FOR THE 20212024 ANNUAL MEETING OF STOCKHOLDERS

April 14, 20219, 2024

INFORMATION ABOUT SOLICITATION AND VOTING

The accompanying proxy is solicited on behalf of the Board of Directors of Passage Bio, Inc. (Passage Bio or the Company) for use at Passage Bio’s 20212024 Annual Meeting of Stockholders (Annual Meeting) to be held via a virtual meeting due to the public health and travel concerns our stockholders may have and recommendations that public health officials have issued and may issue in light of the coronavirus (COVID-19) pandemic.meeting. You will be able to participate in the Annual Meeting and vote during the Annual Meeting via live webcast by visiting www.virtualshareholdermeeting.com/‌PASG2021PASG2024 on Thursday,Tuesday, May 27, 202121, 2024 at 4:30 p.m.9:00 a.m., Eastern Time, and any adjournment or postponement thereof. You will need the control number included on your proxy card or voting instruction form, or included in the e-mail to you if you received the proxy materials by e-mail, as such number will be required in order for stockholders to gain access to the virtual Annual Meeting.

We are making this proxy statement, the accompanying form of proxy and our Annual Report on Form 10-K for the year ended December 31, 20202023 first available to stockholders on or about April 14, 2021.9, 2024. An electronic copy of this proxy statement and Annual Report on Form 10-K are available at https://investors.passagebio.com/financials-and-filings/‌sec- filings.sec-filings.

Internet Availability of Proxy Materials

Under rules adopted by the U.S. Securities and Exchange Commission (the SEC”)SEC), we are furnishing proxy materials to our stockholders primarily via the internet, instead of mailing printed copies to each stockholder. On or about April 14, 2021,9, 2024, we expect to send to our stockholders a Notice of Internet Availability containing instructions on how to access our proxy materials, including our proxy statement and our Annual Report on Form 10-K. The Notice of Internet Availability also provides instructions on how to vote through the internet or by telephone and includes instructions on how to receive paper copies of the proxy materials by mail or an electronic copy of the proxy materials by email.

This process is designed to reduce our environmental impact and lower the costs of printing and distributing our proxy materials without impacting our stockholders’ timely access to this important information. However, if you would prefer to receive printed proxy materials, please follow the instructions included in the Notice of Internet Availability.

GENERAL INFORMATION ABOUT THE MEETING

Purpose of the Annual Meeting

At the Annual Meeting, stockholders will act upon the proposals described in this proxy statement. In addition, we will consider any other matters that are properly presented for a vote at the meeting. We are not aware of any other matters to be submitted for consideration at the meeting. If any other matters are properly presented for a vote at the meeting, the persons named in the proxy, who are officers of the company, have the authority in their discretion to vote the shares represented by the proxy.

Record Date; Quorum

Only holders of record of common stock at the close of business on April 5, 2021,March 28, 2024, the record date, will be entitled to vote at the Annual Meeting. At the close of business on April 5, 2021, 53,977,484March 28, 2024, 61,611,796 shares of common stock were outstanding and entitled to vote.

1


The holders of a majority of the voting power of the shares of stock entitled to vote at the Annual Meeting as of the record date must be present or represented by proxy at the Annual Meeting in order to hold the meeting and conduct business. This presence is called a quorum. Your shares are counted as present at the Annual Meeting if you are present and vote online at the virtual Annual Meeting or if you have properly submitted a proxy.

1

GENERAL PROXY INFORMATION

Voting Rights; Required Vote

Each holder of shares of common stock is entitled to one vote for each share of common stock held as of the close of business on April 5, 2021,March 28, 2024, the record date. You may vote all shares owned by you at such date, including (1) shares held directly in your name as the stockholder of record and (2) shares held for you as the beneficial owner in street name through a broker, bank, trustee or other nominee. Dissenters’ rights are not applicable to any of the matters being voted on.

Stockholder of Record: Shares Registered in Your Name. If on April 5, 2021,March 28, 2024, your shares were registered directly in your name with our transfer agent, Computershare Trust Company, N.A., then you are considered the stockholder of record with respect to those shares. As a stockholder of record, you may vote at the Annual Meeting, or vote in advance through the internet or by telephone, or if you request to receive paper proxy materials by mail, by filling out and returning the proxy card.

Beneficial Owner: Shares Registered in the Name of a Broker or Nominee. If on April 5, 2021,March 28, 2024, your shares were held in an account with a brokerage firm, bank or other nominee, then you are the beneficial owner of the shares held in street name. As a beneficial owner, you have the right to direct your broker on how to vote the shares held in your account, and your broker has enclosed or provided voting instructions for you to use in directing it on how to vote your shares. Because the brokerage firm, bank or other nominee that holds your shares is the stockholder of record, if you wish to attend the Annual Meeting and vote your shares, you must obtain a valid proxy from the firm that holds your shares giving you the right to vote the shares at the Annual Meeting.

Each director will be elected by a plurality of the votes cast at the Annual Meeting. This means that the threetwo individuals nominated for election to the Board of Directors at the Annual Meeting receiving the highest number of “FOR” votes will be elected. You may either vote “FOR” one two or allboth of the nominees or “WITHHOLD” your vote with respect to one two or allboth of the nominees. A “WITHHOLD” will have the same effect as an abstention. You may not cumulate votes in the election of directors. Approval of the ratification of the appointment of our independent registered public accounting firm will be obtained if the holders of a majoritynumber of the votes cast at the Annual Meeting vote “FOR” the proposal exceeds the number of votes “AGAINST” the proposal.

A proxy submitted by a stockholder may indicate that the shares represented by the proxy are not being voted (stockholder withholding) with respect to a particular matter. In addition, a broker may not be permitted to vote on shares held in street name on a particular matternon-routine matters in the absence of instructions from the beneficial owner of the stock (broker non-vote). At this meeting, only the ratification of the appointment of KPMG LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2024, is considered a routine matter. The other proposal presented at the Annual Meeting is a non-routine matter, and therefore a broker may not vote on such matter absent instructions from the beneficial owner of the stock. The shares subject to a proxy which are not being voted on a particular matter because of either stockholder withholding or broker non-votes will count for purposes of determining the presence of a quorum, but are not treated as votes cast and, therefore, will have no effect on the election of directors or the ratification of the appointment of KPMG LLP. Abstentions are voted neither “for” nor “against” a matter, and, therefore, will have no effect on the election of directors or the ratification of the appointment of KPMG LLP, but areLLP. Abstentions will also be counted in the determination of a quorum.

Recommendations of the Board of Directors on Each of the Proposals Scheduled to be Voted on at the Annual Meeting

The Board of Directors recommends that you vote FOR the election of each of the Class I directors named in this proxy statement (Proposal 1), and FOR the ratification of the appointment of KPMG LLP as our independent registered public accounting firm for the fiscal year ending December 31, 20212024 (Proposal 2).

2


None of the directors or executive officers has any substantial interest in any matter to be acted upon, other than elections to office with respect to the directors nominated in Proposal 1.

Voting Instructions; Voting of Proxies

If you are a stockholder of record, you may:

vote online at the Annual Meeting –attend– attend the Annual Meeting online and follow the instructions posted at www.virtualshareholdermeeting.com/PASG2021.PASG2024. You will need the control number included on your proxy card or voting instruction form, or included in the e-mail to you if you received the proxy materials by e-mail;

vote through the internet or by telephone – in order to do so, please follow the instructions shown on your proxy card or Notice of Internet Availability; or

vote by mail – if you request or receive a paper proxy card and voting instructions by mail, simply complete, sign and date the proxy card and return it as soon as possible before the Annual Meeting in the envelope provided.

2

Votes submitted through the internet or by telephone must be received by 11:59 p.m., Eastern Time, on May 26, 2021.20, 2024. Submitting your proxy, whether by telephone, through the internet or by mail if you requested or received a paper proxy card, will not affect your right to vote online should you decide to attend the virtual Annual Meeting.

If you are not the stockholder of record, please refer to the voting instructions provided by your nominee to direct how to vote your shares. If your shares are held in an account with a brokerage firm, bank or other nominee, then you are deemed to be the beneficial owner of your shares and the broker that actually holds the shares for you is the record holder and is required to vote the shares it holds on your behalf according to your instructions. The proxy materials, as well as voting and revocation instructions, should have been forwarded to you by the bank, broker or other nominee that holds your shares. In order to vote your shares, you will need to follow the instructions that your bank, broker or other nominee provides you. The voting deadlines and availability of telephone and Internet voting for beneficial owners of shares held in street name will depend on the voting processes of the bank, broker or other nominee that holds your shares. Therefore, we urge you to carefully review and follow the voting instruction card and any other materials that you receive from that organization.

For Proposal 1, you may either vote “FOR” all of the nominees to the Board of Directors, or you may withhold your vote from any nominee you specify. For Proposal 2, you may vote “FOR” or “AGAINST” or “ABSTAIN” from voting. Your vote is important. Whether or not you plan to attend the Annual Meeting, we urge you to vote by proxy to ensure that your vote is counted.

All proxies will be voted in accordance with the instructions specified on the proxy card. If you sign a physical proxy card and return it without instructions as to how your shares should be voted on a particular proposal at the Annual Meeting, your shares will be voted in accordance with the recommendations of our Board of Directors stated above.

If you do not vote and you hold your shares in street name, and your broker does not have discretionary power to vote your shares, your shares may constitute “broker non-votes” (as described above) and will not be counted in determining the number of shares necessary for approval of the proposals. However, shares that constitute broker non-votes will be counted for the purpose of establishing a quorum for the Annual Meeting.

If you receive more than one proxy card or Notice of Internet Availability, your shares are registered in more than one name or are registered in different accounts. To make certain all of your shares are voted, please follow the instructions included on each proxy card or Notice of Internet Availability and vote each proxy card by telephone, through the internet or by mail. If you requested or received paper proxy materials by mail, please complete, sign, date and return each proxy card to ensure that all of your shares are voted.

Expenses of Soliciting Proxies

We will pay the expenses associated with soliciting proxies. Following the original distribution and mailing of the solicitation materials, we or our agents may solicit proxies by mail, email, telephone, facsimile, by other similar means, or in person. Our directors, officers and other employees, without additional compensation, may solicit proxies personally or in writing, by telephone, email or otherwise. Following the original distribution and mailing of the solicitation materials, we will request brokers, custodians, nominees and other record holders to forward copies of those materials to persons for whom they hold shares and to request authority for the exercise of proxies. In such cases, we, upon the request of the record holders, will reimburse such holders for their reasonable expenses. If you choose to access the proxy materials and/or vote through the internet, you are responsible for any internet access charges you may incur.

3


Revocability of Proxies

A stockholder of record who has given a proxy may revoke it at any time before the closing of the polls by the inspector of elections at the Annual Meeting by:

delivering to our Corporate Secretary (by any means, including facsimile) a written notice stating that the proxy is revoked;

signing and delivering a proxy bearing a later date;

voting again through the internet or by telephone; or

attending and voting online at the Annual Meeting by following the instructions posted at www.virtualshareholdermeeting.com/‌PASG2021PASG2024 (although attendance at the Annual Meeting will not, by itself, revoke a proxy).

Please note, however, that if your shares are held of record by a brokerage firm, bank or other nominee, and you wish to revoke a proxy, you must contact that firm to revoke or change any prior voting instructions.

3

Electronic Access to the Proxy Materials

The Notice of Internet Availability will provide you with instructions regarding how to:

view our proxy materials for the meeting through the internet;

instruct us to mail paper copies of our current or future proxy materials to you; and

instruct us to send our current or future proxy materials to you electronically by email.

Choosing to receive your future proxy materials by email will reduce the impact of our annual meetings of stockholders on the environment and lower the costs of printing and distributing our proxy materials. If you choose to receive future proxy materials by email, you will receive an email next year with instructions containing a link to those materials and a link to the proxy voting site. Your election to receive proxy materials by email will remain in effect until you terminate it.

Voting Results

Voting results will be tabulated and certified by the inspector of elections appointed for the Annual Meeting. The final results will be tallied by the inspector of elections and filed with the SEC in a Current Report on Form 8-K within four business days of the Annual Meeting.

Implications of Being an “Emerging Growth Company” and “Smaller Reporting Company”

We are an “emerging growth company” as that term is used in the Jumpstart Our Business Startups Act of 2012, and a “smaller reporting company” as defined under Rule 405 of the Securities Act of 1933, and, as such, have elected to comply with certain reduced public company reporting requirements. These reduced reporting requirements include reduced disclosure about the company’s executive compensation arrangements and no requirement to have non-binding advisory votes on executive compensation.

4

4


CORPORATE GOVERNANCE STANDARDS AND DIRECTOR INDEPENDENCE

We are committed to good corporate governance practices. These practices provide an important framework within which our Board of Directors and management pursue our strategic objectives for the benefit of our stockholders.

Corporate Governance Guidelines

Our Board of Directors has adopted Corporate Governance Guidelines that set forth expectations for directors, director independence standards, Board committee structure and functions, and other policies for the governance of the company. Our Corporate Governance Guidelines are available without charge on the investor relations section of our website at https://investors.passagebio.com/corporate-governance/documents-and-charters.

Board Composition and Leadership Structure

Our Corporate Governance Guidelines provide that our Board of Directors shall be free to choose its chairperson in any way that it considers in the best interests of our company, and that the Nominating and Governance Committee shall periodically consider the leadership structure of our Board of Directors and make such recommendations to the Board of Directors with respect thereto as the Nominating and Governance Committee deems appropriate. Our Corporate Governance Guidelines also provide that, when the positions of chairperson and Chief Executive Officer are held by the same person, the independent directors may designate a “lead independent director.” In cases in which the chairperson and Chief Executive Officer are the same person, the chairperson schedules and sets the agenda for meetings of the Board of Directors in consultation with the lead independent director, and the chairperson, or if the chairperson is not present, the lead independent director, chairs such meetings. In addition, the responsibilities of the lead independent director include: presiding over executive sessions of independent directors; serving as a liaison between the chairperson and the independent directors; being available, under appropriate circumstances, for consultation and direct communication with stockholders; and performing such other functions and responsibilities as requested by the Board of Directors from time to time.

The positions of Chief Executive Officer and Chairchairperson of our Board of Directors are held by two different individuals (Bruce Goldsmith,(William Chou, M.D. and Maxine Gowen, Ph.D. and Tadataka Yamada, M.D., respectively). This structure allows our Chief Executive Officer to focus on our day-to-day business while our Chairchairperson leads our Board of Directors in its fundamental role of providing advice to and independent oversight of management. Dr. Chou’s deep medical knowledge as well as his experience in various executive positions in life sciences companies makes him well-suited for this day-to-day operational role, while Dr. Gowen’s extensive experience in leadership roles at life sciences companies with respect to drug discovery, corporate strategy, and operations allows her to perform an oversight function separate from management. Our Board of Directors believes such separation is appropriate, as it enhances the accountability of the Chief Executive Officer to the Board of Directors and strengthens the independence of the Board of Directors from management. Any changes to the leadership structure of our Board of Directors, if made, will be promptly disclosed on the Investor Relations section of our website and in our proxy materials. Our Board of Directors, in its sole discretion, may seek input from our stockholders on the leadership structure of our Board of Directors.

Cybersecurity Risk Oversight

Our Board of Directors recognizes the critical importance of maintaining the trust and confidence of all of our stakeholders. Our business depends on the efficient and uninterrupted operation of our information technology systems and those of our third-party vendors. Our Board of Directors is actively involved in oversight of our risk management program, and cybersecurity represents an important component of our risk management and compliance program.

Our cybersecurity policies, standards, processes and practices are fully integrated into our enterprise-wide risk management and compliance program, overseen by our Audit Committee, and based on recognized frameworks established by the National Institute of Standards and Technology, the International Organization for Standardization and other applicable industry standards. In general, we seek to address cybersecurity risks through a comprehensive, cross-functional approach that is focused on preserving the confidentiality, security and availability of the information that we collect and store by identifying, preventing and mitigating cybersecurity threats and effectively responding to cybersecurity incidents when they occur.

Our Board of Directors, with leadership from our Audit Committee, oversees our cybersecurity risk management process. The Audit Committee receives regular presentations and reports on cybersecurity risks, which address a wide range of topics including recent developments, evolving standards, vulnerability assessments, the threat environment, technological trends and information security considerations arising with respect to our peers and third parties. The Board of Directors and the Audit Committee also receive prompt and timely information regarding any cybersecurity incident that meets established reporting thresholds, as well as ongoing updates regarding any such incident until it has been addressed. On a periodic basis, the Board of Directors, through the Audit Committee, discuss our approach to cybersecurity risk management with our Executive Director of IT.

5

Board’s Role in Risk Oversight

Our Board of Directors believes that open communication between management and the Board of Directors is essential for effective risk management and oversight. Our Board of Directors meets with our Chief Executive Officer and other members of the senior management team at least quarterly at Board of Director meetings where among other topics, they discuss strategy and oversight on areas of material risk to the Company, including operational, research and development activities, financial, legal and regulatory, competitive, and strategic and reputational risks in the context of reports from the management team and evaluate the risks inherent in significant transactions. While our Board of Directors is ultimately responsible for risk oversight, our Board committees assist the Board of Directors in fulfilling its oversight responsibilities in certain areas of risk.

The Audit Committee assists our Board of Directors in fulfilling its oversight responsibilities with respect to risk management in the areas of internal control over financial reporting, disclosure controls and procedures, cybersecurity and certain corporate, legal and regulatory risks. On an annual basis, our Audit Committee reviews the management team’s assessment of business risk, compliance risks and disclosure control and procedure risks, with an emphasis on short-term and intermediate-term risks, and summarizes and discusses these risks with our Board of Directors. The Compensation Committee assists our Board of Directors in assessing risks created by the incentives inherent in our compensation policies. The Nominating and Governance Committee assists our Board of Directors in fulfilling its oversight responsibilities with respect to corporate governance and the management of certain corporate, legal and regulatory risks.risks, including environmental, social and corporate governance matters.

Director Independence

Our common stock is listed on the Nasdaq Global Select Market. Under the rules of the Nasdaq Stock Market, independent directors must constitute a majority of a listed company’s Board of Directors. In addition, the rules of the Nasdaq Stock Market require that, subject to specified exceptions, each member of a listed company’s Audit, Compensation and Nominating and Governance Committees must be an “independent director”.director.” Under the rules of the Nasdaq Stock Market, a director will only qualify as an “independent director” if, in the opinion of that company’s Board of Directors, that person does not have a relationship that would interfere with the exercise of independent judgment in carrying out the responsibilities of a director. Additionally, Compensation Committee members must not have a relationship with the listed company that is material to the director’s ability to be independent from management in connection with the duties of a Compensation Committee member.

Audit Committee members must also satisfy the independence criteria set forth in Rule 10A-3 under the Securities Exchange Act of 1934, as amended (Exchange Act).

Our Board of Directors has undertaken a review of the independence of each director and considered whether each director has a material relationship with us that could compromise his or her ability to exercise independent judgment in carrying out his or her responsibilities. As a result of this review, our Board of Directors determined that Athena

5


Countouriotis M.D., Maxine Gowen, Patrick Heron,Ph.D., Saqib Islam, Sandip Kapadia, Liam Ratcliffe, Tom WoiwodeDerrell Porter, M.D., and Tadataka Yamada,Dolan Sondhi, Ph.D., representing eightsix of our nineseven incumbent directors, are “independent directors” as defined under the applicable rules and regulations of the SEC and the listing requirements and rules of the Nasdaq Stock Market. Our Board of Directors has also determined that Derrell Porter, a nominee for our Board of Directors, is an “independent director” as defined under the applicable rules and regulations of the SEC and the listing requirements and rules of the Nasdaq Stock Market. In making these determinations, our Board of Directors reviewed and discussed information provided by the directors and us with regard to each directors’director’s business and personal activities and relationships as they may relate to us and our management, including the beneficial ownership of our capital stock by each non-employee director and any affiliates.

Committees of Our Board of Directors

Our Board of Directors has established an Audit Committee, a Compensation Committee and a Nominating and Governance Committee, each of which has the composition and responsibilities described below. Members serve on these committees until their resignation or until otherwise determined by our Board of Directors. Each of these committees has a written charter, copies of which are available without charge on the investor relations section of our website at https://investors.passagebio.com/www.passagebio.com/investors-and-news/corporate-governance/documents-and-charters.default.aspx.

Audit Committee

Our Audit Committee is composed of Mr. Kapadia, Mr. Islam, and Mr. Heron. Mr. Kapadia is the Chair of our Audit Committee. Following our Annual Meeting, we expect to appoint Dr. Porter to our Audit Committee. The composition of our Audit Committee meets the requirements for independence under the current Nasdaq Stock Market and SEC rules and regulations. Each member of our Audit Committee is financially literate. In addition, our Board of Directors has determined that Mr. Kapadia is an “audit committee financial expert” as defined in Item 407(d)(5)(ii) of Regulation S-K promulgated under the Securities Act. Our Audit Committee is directly responsible for, among other things:

Our Audit Committee is composed of Mr. Kapadia, Dr. Countouriotis, and Mr. Islam. Mr. Kapadia is the Chair of our Audit Committee. The composition of our Audit Committee meets the requirements for independence under the current Nasdaq Stock Market and SEC rules and regulations. Each member of our Audit Committee is financially literate. In addition, our Board of Directors has determined that Mr. Kapadia is an “audit committee financial expert” as defined in Item 407(d)(5)(ii) of Regulation S-K promulgated under the Securities Act. Our Audit Committee is directly responsible for, among other things:

selecting and hiring our independent registered public accounting firm;

the qualifications, independence and performance of our independent auditors;

the preparation of the audit committee report to be included in our annual proxy statement;

our compliance with certain legal and regulatory requirements, including disclosure controls;

6

overseeing our cybersecurity risk management program;

assisting the Board of Directors with risk assessment and management,

our accounting and financial reporting processes, including our financial statement audits and the integrity of our financial statements; and

reviewing and approving related-person transactions.

Compensation Committee

Our Compensation Committee is composed of Dr. Woiwode,Countouriotis, Dr. CountouriotisGowen and Dr. Yamada.Porter. Dr. WoiwodeCountouriotis is the Chair of our Compensation Committee. The composition of our Compensation Committee meets the requirements for independence under the current Nasdaq Stock Market and SEC rules and regulations. Our Compensation Committee is responsible for, among other things:

evaluating, recommending, approving and reviewing executive officer compensation arrangements, plans, policies and programs;

evaluating and providing input forrecommending non-employee director compensation arrangements for determination by the Board;Board of Directors;

6


providing oversight foradministering our cash-based and equity-based compensation plans; and

overseeing our compliance with regulatory requirements associated with the compensation of directors, officers and employees.

The Compensation Committee has the sole authority and responsibility, subject to any approval by the Board of Directors which the Compensation Committee or legal counsel determines to be desirable or required by applicable law or the Nasdaq rules, to determine all aspects of executive compensation packages for the Chief Executive Officer and other executive officers. The Compensation Committee also makes recommendations to our Board of Directors regarding the form and amount of compensation of non-employee directors. The Compensation Committee may take into account the recommendations of the Chief Executive Officer with respect to compensation of the other executive officers, and the recommendations of the Board of Directors or any member of the Board of Directors with respect to compensation of the Chief Executive Officer and other executive officers.

The Compensation Committee engaged an independent executive compensation consulting firm, Radford, which is part of the Rewards Solutions practice at Aon plc,Pearl Meyer and Partners, LLC., (Pearl Meyer) to evaluate our executive compensation and Board of Directors compensation program and practices and to provide advice and ongoing assistance on these matters for the fiscal year ended December 31, 2020.matters. Specifically, RadfordPearl Meyer was engaged to:

provide compensation-related data for adevelop peer group of companies to serve as a basisgroups for assessing competitive compensation practices;executive and non-employee director compensation;

reviewconduct benchmarking of cash and assess our current Board of Directors, Chief Executive Officer and other executive officerequity-based compensation policieslevels and practices for executives and equity profile, relative to market practices;non-employee directors, as well as certain company-wide benchmarking studies;

reviewrecommend certain compensation actions and assess our current executive compensation program relative to market to identify any potential changes or enhancements to be brought toawards based on the attentionresults of the Compensation Committee;benchmarking, the Company’s compensation philosophy, strategy, goals, and culture;

review market practices regarding base salary, bonusdevelop frameworks to assist the Committee in managing the Company’s equity-based compensation program; and equity programs.

advise the Committee on other compensation-related topics that may arise during the course of the year

Representatives of RadfordPearl Meyer met informally with the Chair of the Compensation Committee and attended the regular meetings of the Compensation Committee, including executive sessions from time to time without any members of management present. During the fiscal year ended December 31, 2020, Radford2023, Pearl Meyer worked directly with the Compensation Committee (and not on behalf of management) to assist the committee in satisfying its responsibilities and undertook no projects for management without the committee’s prior approval. The Compensation Committee has determined that none of the work performed by RadfordPearl Meyer during the fiscal year ended December 31, 20202023 raised any conflict of interest.

7

Nominating and Governance Committee

Our Nominating and Governance Committee is composed of Dr. Ratcliffe, Mr. HeronGowen, Dr. Porter and Dr. Yamada.Sondhi. Dr. RatcliffeGowen is the Chair of our Nominating and Governance Committee. Following our Annual Meeting, we expect to appoint Ms. Gowen to our Nominating and Governance Committee. Our Nominating and Governance Committee is responsible for, among other things:

identifying, considering and recommending candidates for membership on our Board of Directors;

overseeing the process of evaluating the performance of our Board of Directors; and

advising our Board of Directors on corporate governance matters, including environmental, social and certain corporate, legal and regulatory risks.governance issues.

7


Codes of Conduct and Ethics

Our Board of Directors has adopted a codeCode of conductConduct and ethicsEthics that applies to all of our employees, officers and directors, including our Chief Executive Officer, Chief Financial Officer and other executive and senior financial officers. We intend to disclose future amendments to certain provisions of our codeCode of conductConduct and ethics,Ethics, or waivers of these provisions, on our website or in public filings to the extent required by the applicable rules. The full text of our codeCode of conductConduct and ethicsEthics is posted on the investor relations section of our website at https://investors.passagebio.com/www.passagebio.com/investors-and-news/corporate-governance/documents-and-charters.default.aspx.

Corporate Social Responsibility

We believe that corporate social responsibility (CSR) initiatives are important to our business and to creating sustainable value for our stockholders and wider stakeholder group. Our Board of Directors and management are committed to these initiatives and believe these efforts will benefit our employees, partners, and the communities in which we operate.

Anti-hedging

We have adopted an Insider Trading Policy that that applies to all of our employees, officers and directors, including our Chief Executive Officer and other executive officers, which prohibits such individuals from purchasing financial instruments, or otherwise engaging in transactions, that hedge or offset, or are designed to hedge or offset, any decrease in market value of our common stock, such as prepaid variable forward contracts, equity swaps, collars, forward sale contracts and exchange funds.

Compensation Recovery Policy

On October 12, 2023, our Board of Directors adopted and our Compensation Committee administers, a Compensation Recovery Policy (Clawback Policy) to comply with new rules and regulations promulgated by the SEC, including Rule 10D-1 of the Exchange Act that is applicable to all employees who are officers for purposes of Section 16 of the Exchange Act, including current and former Section 16 officers (Covered Employees). The Clawback Policy allows us to recover or “clawback” certain incentive-based compensation from Covered Employees in the event of a restatement of our financial statements due to material noncompliance with any financial reporting requirements under the federal securities laws. Under the Clawback Policy, if the restatement would result in any incentive-based compensation paid during the three years preceding the restatement to have been lower had it been calculated based on such restated results, we must recover the amounts in excess of what would have been paid under the restatement from any participant who received such incentive-based compensation.

Compensation Committee Interlocks and Insider Participation

During 2020,2023, Dr. Countouriotis, Dr. Gowen Dr. Porter, and Dr. Woiwode Dr. Countouriotis and Dr. Yamada served on our Compensation Committee. Dr. Woiwode resigned from the Board of Directors on July 26, 2023. None of our current executive officers has served as a member of the Board of Directors, or as a member of the Compensation or similar committee, of any entity that has one or more executive officers who served on our Board of Directors or Compensation Committee during the fiscal year ended December 31, 2020.2023.

Board and Committee Meetings and Attendance

The Board of Directors and its committees meet regularly throughout the year and also hold special meetings and act by written consent from time to time. During 2020,2023, the Board of Directors held eightsix meetings including telephonic meetings; the Audit Committee held sixfive meetings; the Compensation Committee held fivesix meetings; and the Nominating and Governance Committee held three meeting.six meetings. During 2020, none of the directors2023, each director attended fewer thanat least 75% of the aggregate of the total number of meetings held by the Board of Directors during his or her tenure and the total number of meetings held by all committees of the Board of Directors on which such director served during his or her tenure. The independent members of the Board of Directors also meet separately without management directors on a regular basis to discuss such matters as the independent directors consider appropriate.

8

Board Attendance at Annual Stockholders’ Meeting

We invite and encourage each member of our Board of Directors to attend our annual meetings of stockholders. We do not have a formal policy regarding attendance of our annual meetings of stockholders by the members of our Board of Directors.

8


Table All members of Contentsour Board of Directors attended our 2023 Annual Meeting of Stockholders.

Communication with Directors

Stockholders and interested parties who wish to communicate with our Board of Directors, non-management members of our Board of Directors as a group, a committee of the Board of Directors or a specific member of our Board of Directors (including our Chair) may do so by letters addressed to:

Passage Bio, Inc.


c/o Corporate Secretary


One Commerce Square


2005 Market Street, 39th39th Floor


Philadelphia, PA 19103

All communications by letter addressed to the attention of our Corporate Secretary will be reviewed by the Corporate Secretary and provided to the members of the Board of Directors unless such communications are unsolicited items, sales materials and other routine items and items unrelated to the duties and responsibilities of the Board of Directors.

Considerations in Evaluating Director Nominees

The Nominating and Governance Committee is responsible for identifying, considering, and recommending candidates to the Board of Directors for Board membership. A variety of methods are used to identify and evaluate director nominees, with the goal of maintaining and further developing a diverse, experienced, and highly qualified Board of Directors. Candidates may come to our attention through current members of our Board of Directors, professional search firms, stockholders or other persons.

The Nominating and Governance Committee will recommend to the Board of Directors for selection all nominees to be proposed by the Board of Directors for election by the stockholders, including approval or recommendation of a slate of director nominees to be proposed by the Board of Directors for election at each annual meeting of stockholders, and will recommend all director nominees to be appointed by the Board of Directors to fill interim director vacancies.

Our Board of Directors encourages the selection of directors who will contribute to the company’s overall corporate goals. The Nominating and Governance Committee may from time to timetime-to-time review and recommend to the Board of Directors the desired qualifications, expertise, and characteristics of directors, including such factors as business experience, diversity and personal skills in life sciences and biotechnology, finance, marketing, financial reporting and other areas that are expected to contribute to an effective Board of Directors. Exceptional candidates who do not meet all of these criteria may still be considered. In evaluating potential candidates for the Board of Directors, the Nominating and Governance Committee considers these factors in the light of the specific needs of the Board of Directors at that time.

In addition, under our Corporate Governance Guidelines, a director is expected to spend the time and effort necessary to properly discharge such director’s responsibilities. Accordingly, a director is expected to regularly attend meetings of the Board of Directors and committees on which such director sits, and to review prior to meetings material distributed in advance for such meetings. Thus, the number of other public company boards and other boards (or comparable governing bodies) on which a prospective nominee is a member, as well as his or her other professional responsibilities, will be considered. Also, under our Corporate Governance Guidelines, there are no limits on the number of three-year terms that may be served by a director. However, in connection with evaluating recommendations for nomination for reelection, the Nominating and Governance Committee considers director tenure. We value diversity on a company-wide basis but have not adopted a specific policy regarding Board diversity.

Stockholder Recommendations for Nominations to the Board of Directors

The Nominating and Governance Committee will consider properly submitted stockholder recommendations for candidates for our Board of Directors who meet the minimum qualifications as described above. The Nominating and Governance Committee does not intend to alter the manner in which it evaluates candidates, including the minimum criteria set forth above, based on whether or not the candidate was recommended by a stockholder. A stockholder of record can nominate a candidate for election to the Board of Directors by complying with the procedures in Article I,

9


Section 1.12 of our bylaws.Amended and Restated Bylaws (the Bylaws). Any eligible stockholder who wishes to submit a nomination should review the requirements in the bylawsBylaws on nominations by stockholders. Any nomination should be sent in writing to our Corporate Secretary, Passage Bio, Inc., One Commerce Square, 2005 Market Street, 39th39th Floor, Philadelphia, PA 19103. Submissions must include the full name of the proposed nominee, complete biographical information, a description of the proposed nominee’s qualifications as a director, other information regarding the nominee and proposing stockholder as specified in our bylaws,the Bylaws, and a representation thatcertain representations regarding the nominating stockholder is a beneficial or record holder of our stock.nomination. Any such submission must be accompanied by the written consent of the proposed nominee to be named as a nominee and to serve as a director if elected. These candidates are evaluated at meetings of the Nominating and Governance Committee and may be considered at any point during the year. If any materials are provided by a stockholder in connection with the recommendation of a director candidate, such materials are forwarded to the Nominating and Governance Committee.

9

Additional information regarding the process for properly submitting stockholder nominations for candidates for membership on our Board of Directors is set forth below under “Stockholder Proposals to Be Presented at Next Annual Meeting.” In addition to satisfying the foregoing requirements under the Bylaws, to comply with the universal proxy rules, stockholders who intend to solicit proxies in support of director nominees other than the Company’s nominees for the 2025 Annual Meeting of Stockholders must provide notice that sets forth the information required by Rule 14a-19 under the Exchange Act.

10


PROPOSAL NO. 1


ELECTION OF CLASS I DIRECTORS

Our Board of Directors is divided into three classes. Each class serves for three years, with the terms of office of the respective classes expiring in successive years. Directors and director nominees in Class I will stand for election at this Annual Meeting. The terms of office of directors in Class II and Class III do not expire until the annual meetings of stockholders to be held in 20222025 and 2023,2026, respectively. Our Nominating and Governance Committee recommended to our Board of Directors, and our Board of Directors nominated Dr. GoldsmithChou and Dr. Yamada,Porter, each an incumbent Class I director, and Dr, Porter for election as Class I directors at the Annual Meeting. At the recommendation of our Nominating and Governance Committee, our Board of Directors proposes that each of the Class I nominees be elected as a Class I director for a three-year term expiring at the annual meeting of stockholders to be held in 20242027 and until such director’s successor is duly elected and qualified or until such director’s earlier resignation or removal.

Each director will be elected by a plurality of the votes present online at the virtual Annual Meeting or represented by proxy at the Annual Meeting and entitled to vote on the election of directors. This means that the threetwo individuals nominated for election to the Board of Directors at the Annual Meeting receiving the highest number of “FOR” votes will be elected. You may either vote “FOR” one two or allboth of the nominees or “WITHHOLD” your vote with respect to one two or allboth of the nominees. A “WITHHOLD” vote will have the same effect as an abstention. Shares represented by proxies will be voted “FOR” the election of each of the Class I nominees, unless the proxy is marked to withhold authority to so vote. You may not cumulate votes in the election of directors. If any nominee for any reason is unable to serve, the proxies may be voted for such substitute nominee as the proxy holders, who are officers of our company, might determine. Each nominee has consented to being named in this proxy statement and to serve if elected. Proxies may not be voted for more than threetwo directors.

Nominees to the Board of Directors

The nominees and their ages as of December 31, 2020March 28, 2024 are provided in the table below. Additional biographical information for each nominee is set forth in the text below the table.

Name

Age

Class

Name

William Chou, M.D.

Age

51

Class

Bruce Goldsmith, Ph.D.

54

Class I Director

Derrell Porter, M.D.(1)(2)

50

53

Class I Director

Tadataka Yamada, M.D.(2)(3)

75

Class I Director


(1)Expected to be appointed as a member of our Audit Committee
(2)(1)Member of our Compensation Committee

(3)(2)Member of our Nominating and Governance Committee

Bruce A. Goldsmith, Ph.D., William Chou, M.D.has served as our President and Chief Executive Officer and President and as a member of our boardBoard of directorsDirectors since January 2020.October 2022. Dr. GoldsmithChou is an accomplished executive with nearly 20 years of healthcare experience across a range of development and commercialization roles. Dr. Chou previously served as an Advisor and Venture Partner at Deerfield VenturesCEO of Aruvant Sciences (Aruvant), a clinical-stage biopharmaceutical company focused on developing gene therapies for rare disease, from JanuaryNovember 2019 to January 2020. From AprilOctober 2022. Prior to joining Aruvant, from May 2008 to October 2019, to January 2020, Dr. Goldsmith alsoChou served as Interim Chief Executive Officerin a variety of Civetta Therapeutics.leadership roles at Novartis Pharma AG (Novartis), including Vice President and Global Disease Lead for Novartis’ Cell and Gene Therapy where he oversaw the global commercial launch of Kymriah®, the first CAR-T cell therapy. Prior to that role, Dr. Goldsmith served initially as Chief Business OfficerChou led the Kymriah® lymphoma clinical development program to approvals in the United States, Europe, Australia, Canada and then as Chief Operating OfficerJapan. Before joining Novartis, Dr. Chou worked at Lycera, Corp. from April 2013 to January 2019. From 2008 to 2012, Dr. Goldsmith served as Vice President and then Senior Vice President of Corporate Development at Allos Therapeutics. Prior to Allos, Dr. Goldsmith served in various leadership roles at GPC Biotech in 2007 and Tibotec Therapeutics, a subsidiary of Johnson & Johnson, from 2005 to 2007. Dr. Goldsmith also previously held various positions at Johnson & Johnson in oncology global strategic marketing, business development and licensing and acquisition finance. Prior to joining Johnson & Johnson, Dr. Goldsmith was a research fellow at Novartis Pharma, K.K.,the Boston Consulting Group where he conducted scientific research in a neurodegeneration drug discovery group.focused on commercial and clinical pharmaceutical strategy. Dr. Goldsmith received a B.A. in BiologyChou holds an MBA from Colgate University, a Ph.D. in Biology with a research thesis in neurosciencethe Yale School of Management, an MD from the University of Pennsylvania,Pittsburgh School of Medicine, and an M.B.A.AB in politics and economics from ColumbiaPrinceton University. Dr. Chou completed his residency in internal medicine at Yale New Haven Hospital and his fellowship in geriatrics at Yale University. We believe that Dr. GoldsmithChou is qualified to serve on our boardBoard of directorsDirectors due to his experienceleadership experiences in the biopharmaceuticallife science and biotechnology industry.pharmaceutical industry and his experience of guiding a development program to commercial launch.

Derrell D. Porter, M.D.currently has served as member of our Board of Directors since May 2021. Dr. Porter has served as Chief Executive Officer and as member of the board of directors of cTRL Therapeutics, Inc., a private company, since November 2023. Dr. Porter has served on the board of directors of Acumen Pharma, a public company, since January 2023, and also serves on the boards of directors of several private companies. Previously, Dr. Porter served as Founder & CEOand Chief Executive Officer at Cellevolve Bio, Inc., which was incorporated ina privately held biotechnology company from March 2020.2020 to November 2023. Prior to that, Dr. Porter served as SVP and Head of Commercial at Atara Biotherapeutics, Inc. from May 2017 to

11


October 2019. Prior to joining Atara, Dr. Porter served as a Vice President with Gilead Sciences from April 2013 to May 2017, where he was responsible for corporate strategy, commercial planning, and global launch preparation for all of Gilead’s therapeutic areas. Previously, Dr. Porter was at AbbVie and Amgen, where he served in multiple US, EU and global roles of increasing responsibility in strategy, corporate development, business unit management, and sales & marketing. Dr. Porter began his career at McKinsey & Company in Los Angeles as part of the West Coast Health Care Practice. Dr. Porter currently serves on the boards of directors of several private companies. Dr. Porter holds an MDM.D. from the University of Pennsylvania, where he was a Twenty First Century Scholar, an MBAM.B.A. from The Wharton School and a bachelor’sBachelor’s degree in neuroscience from UCLA.the University of California Los Angeles. We believe Dr. Porter is qualified to serve on our boardBoard of directorsDirectors due to his biopharmaceutical, corporate development and global marketing experience.

Tadataka Yamada, M.D. has served as Chairman of our board of directors since July 2017. Dr. Yamada has served as a Venture Partner at Frazier Life Sciences since June 2015. From September 2017 to January 2020, Dr. Yamada served in a non-employee capacity as our President and Treasurer. From June 2011 to June 2015, Dr. Yamada served as the Chief Medical and Scientific Officer of Takeda Pharmaceutical Company Ltd. From 2006 to 2011, Dr. Yamada served as President of the Global Health Program of the Bill & Melinda Gates Foundation. Previously, Dr. Yamada served as Chairman of Research and Development of GlaxoSmithKline Inc., a multinational pharmaceutical company, and he previously held research and development positions at SmithKline Beecham. Prior to that, Dr. Yamada served as Chairman of the Department of Internal Medicine at the University of Michigan Medical School and Physician-in-Chief of the University of Michigan Medical Center. Dr. Yamada is a member of the National Academy of Medicine, a Fellow of the Imperial College of Medicine, a Master of the American College of Physicians, a Fellow of the Royal College of Physicians, a Member of the American Academy of Arts and Sciences and a past-President of the American Gastroenterological Association and the Association of American Physicians. Dr. Yamada currently serves on the boards of directors Athira Pharma, Inc. and Phathom Pharmaceuticals, Inc. Dr. Yamada previously served on the boards of directors of Takeda Pharmaceutical Company Ltd, GlaxoSmithKline PLC., CSL Limited, a biotechnology company, and Agilent Technologies, Inc., a scientific instrument manufacturing and clinical diagnostics company. Dr. Yamada received a B.A. in History from Stanford University and an M.D. from New York University School of Medicine. We believe that Dr. Yamada is qualified to serve on our board of directors due to his extensive research and experience in drug development, as well as his service as a director or officer of various biotechnology and biopharmaceutical companies.

10

Continuing Directors

The directors who are serving for terms that end following the Annual Meeting and their ages as of March 28, 2024 are provided in the table below. Additional biographical information for each nominee is set forth in the text below the table.

Name

Age

Class

Name

Maxine Gowen, Ph.D. (1)(2)(3)

Age

66

Class

 II Director

Athena Countouriotis,Contouriotis, M.D.(2)(4)(5)

49

52

Class III Director

Maxine Gowen,Saqib Islam (5)

54Class III Director
Sandip Kapadia (6)54Class III Director
Dolan Sondhi, Ph.D.(4)(7)

63

53

Class II Director

Saqib Islam(1)

51

Class III Director

Sandip Kapadia(1)

50

Class III Director

Liam Ratcliffe, M.D., Ph.D.(3)

57

Class II Director

Thomas Woiwode, Ph.D. (2)

49

Class II Director


(1)Chairperson of our Board of Directors

(2)Chairperson of our Nominating and Governance Committee

(3)Member of our Compensation Committee

(4)Chairperson of our Compensation Committee

(5)Member of our Audit Committee

(2)Member(6)Chairperson of our CompensationAudit Committee

(3)(7)Member of our Nominating and Governance Committee
(4)Expected to be appointed as a member of our Nominating and Governance Committee

Athena Countouriotis, M.D.has served as a member of our boardBoard of directorsDirectors since February 2020. Dr. Countouriotis has served as Chief Executive Officer and Chairperson of the board of directors of Avenzo Therapeutics, a private oncology therapeutics company, since October 2022. Dr. Countouriotis currently serves on the board of directors of BioMarin Pharmaceutical Inc., a public pharmaceutical company, Iovance Biotherapeutics, Inc., a public oncology therapeutics company, Recludix Therapeutics, Inc., a private oncology therapeutics company, Leal Therapeutics, Inc., a private central nervous system diseases company, and Capstan Therapeutics, Inc, a private cell therapy company. Dr. Countouriotis served as Chief Executive Officer and a member of the board of directors of Turning Point Therapeutics Inc. sincefrom September 2018 and from May 2018 to September 2018, she servedAugust 2022, and as Chief Medical Officer of Turning Point Therapeutics.Therapeutics from May 2018 to September 2018. Dr. Countouriotis served as Senior Vice President and Chief Medical Officer for Adverum Biotechnologies, Inc. from June 2017 to May 2018, and before that served as Senior Vice President, Chief Medical Officer of Halozyme Therapeutics, Inc. from January 2015 to May 2017. Dr. Countouriotis also served as Chief Medical

12


Officer of Ambit Biosciences Corporation from February 2012 until Ambit’s acquisition by Daiichi Sankyo Company in November 2014. Earlier in her career, Dr. Countouriotis led various clinical development organizations within Pfizer Inc. and Bristol-Myers Squibb Company for oncology therapeutics. Dr. Countouriotis currently serves on the board of directors of Iovance Biotherapeutics, Inc., a public oncology therapeutics company.In addition, Dr. Countouriotis previously served on the board of directors of Trovagene, Inc.,Cardiff Oncology, a public oncology therapeutics company. Dr. Countouriotis earned a B.S. from the University of California, Los Angeles, and an M.D. from Tufts University School of Medicine. Dr. Countouriotis received her initial training in pediatrics at the University of California, Los Angeles, and additional training at the Fred Hutchinson Cancer Research Center in the Pediatric Hematology/Oncology Program. We believe that Dr. Countouriotis is qualified to serve on our boardBoard of directorsDirectors due to her broad oncology biotech leadership experience and history of guiding multiple development programs to approval.

Maxine Gowen, Ph.D. Ph.D. has served as a member of our boardBoard of directorsDirectors since February 2021, and as Chairperson of the Board of Directors since September 2021. Dr. Gowen hascurrently serves on the boards of directors for Merus N.V. and Aclaris Therapeutics, Inc., each a public biotechnology company. Dr. Gowen served as Chief Executive Officer of Tamuro Bio sincefrom July 2019. Dr. Gowen served2019 to December 2021, and prior to that, as the founding President and Chief Executive Officer of Trevena, Inc., from 2007 to October 2018, and haswhere she served as a member of Trevena’s board of directors since 2008.from 2008 to 2021. Dr. Gowen previously held a variety of leadership roles at GlaxoSmithKline over a period of 15 years. She also currently serves on the boards of directors for Idera Pharmaceuticals, Inc., Akebia Therapeutics, Inc., and Aclaris Therapeutics, Inc., each a public biotechnology company, as well as two private companies.Additionally, Dr. Gowen also currently servesserved on the board of Akebia Therapeutics, Inc from 2014 to 2021, the board of Idera Pharmaceuticals from 2016 to 2022, the board of directors and executive committee of BIO, an industry association, from 2008 to 2018, and the board of directors and executive committee of Life Sciences Pennsylvania, an industry association.association from 2016 to 2021. Dr. Gowen received a B.Sc. in biochemistry from the University of Bristol, U.K., a Ph.D. in cell biology from the University of Sheffield, U.K., and an M.B.A. from the Wharton School of the University of Pennsylvania. We believe that Dr. Gowen is qualified to serve on our boardBoard of directorsDirectors due to her leadership experiences in the life science and pharmaceutical industry.

Saqib IslamSandip Kapadia has served as a member of our Board of Directors since December 2019. Mr. Kapadia has served as the Chief Financial Officer of Harmony Biosciences Holdings, Inc., a public biopharmaceutical company, since March 2021. Mr. Kapadia has served on the board of directors of Molecular Partners AG, a public company, since April 2020. Mr. Kapadia previously served as the Chief Financial Officer for Intercept Pharmaceuticals, Inc. from July 2016 to March 2021. Prior to that, Mr. Kapadia served in various leadership capacities within finance over 19 years at Novartis International AG and Novartis affiliates in the United Kingdom, Netherlands, Switzerland and the U.S. Mr. Kapadia previously served on the board of directors of VectivBio AG from October 2020 to July 2023. Mr. Kapadia received a B.S. in Accounting from Montclair State University and an M.B.A. from Rutgers University, and is also a U.S. Certified Public Accountant. We believe that Mr. Kapadia is qualified to serve on our Board of Directors due to his leadership experience in the biopharmaceutical industry and finance expertise.

11

Saqib Islam has served as a member of our Board of Directors since March 2019. Mr. Islam has served as Chief Executive Officer and a member of the board of directors of SpringWorks Therapeutics, Inc., a public biopharmaceutical company, since August 2018, and from August 2017 to August 2018, he served as Chief Financial Officer and Chief Business Officer of SpringWorks.SpringWorks Therapeutics. Mr. Islam has also served on the board of directors for ARS Pharmaceuticals, Inc., a public biopharmaceutical company, since July 2017. From February 2016 to August 2017, Mr. Islam served as Chief Business Officer at Moderna Therapeutics, Inc., a biotechnology company. From February 2013 to February 2016, Mr. Islam served as Executive Vice President, Chief Strategy and Portfolio Officer at Alexion Pharmaceuticals, Inc., a pharmaceutical company. Prior to joining Alexion, Mr. Islam worked for more than 25 years in international business management with a focus on business development, strategic decision-making and planning and capital markets, previously holding managing director positions at Morgan Stanley and Credit Suisse. Mr. Islam currently serves on the board of directors of Silverback Therapeutics, Inc. Mr. Islam received a B.A. in Communications from McGill University and a J.D. from Columbia Law School. We believe that Mr. Islam is qualified to serve on our boardBoard of directorsDirectors due to his experience and expertise in operations management and executive leadership at various biopharmaceutical and biotechnology companies.

Sandip Kapadia has served as member of our board of directors since December 2019. Mr. Kapadia has served as the Chief Financial Officer of Harmony Biosciences Holdings, Inc. since March 2021. Mr. Kapadia previously served as the Chief Financial Officer for Intercept Pharmaceuticals, Inc. from July 2016 to March 2021. Previously, Mr. Kapadia served in various leadership capacities within finance over 19 years at Novartis International AG and Novartis affiliates in the United Kingdom, Netherlands, Switzerland and the U.S. Mr. Kapadia currently serves on the board of directors of Molecular Partners AG and Vective Bio AG. Mr. Kapadia received a B.S. in Accounting from Montclair State University and an M.B.A. from Rutgers University, and is also a U.S. Certified Public Accountant. We believe that Mr. Kapadia is qualified to serve on our board of directors due to his leadership experience in the biopharmaceutical industry and finance expertise.

Liam Ratcliffe, M.D.,Dolan Sondhi, Ph.D. has served as a member of our boardBoard of directorsDirectors since July 2023. Dr. Sondhi currently serves as a Professor of Research in Genetic Medicine at Weill Cornell Medical College, a position she has held since November 2015. Dr. Sondhi also holds a number of appointments at Weill Cornell Medical College, including as an Elected Member of the Weill Cornell Medicine Mentoring Academy since June 2020, an Associate Director of the Belfer Gene Therapy Core Facility since September 2019.2012, and Product Manager for all Neurological Gene Therapy Projects for the Department of Genetic Medicine since January 2000. In addition, Dr. RatcliffeSondhi has served as a council member for the Head of Biotechnology at Access IndustriesGerson Lehrman Group, a financial and global information services company, and as an advisor to Guidepoint, an expert network, since April 2019. From September 2008 to April 2019,January 2018. Dr. Ratcliffe served as Managing Director at New Leaf Venture Partners,Sondhi holds a healthcare venture capital firm, where he focused on investing in therapeutics and therapeutic platform companies. Prior to joining New Leaf, Dr. Ratcliffe held various positions of increasing responsibility at Pfizer Inc., a multinational pharmaceutical corporation, including Senior Vice President and Development Head for Neuroscience, and Worldwide Head of Clinical Research and Development. Dr. Ratcliffe currently serves on the board of directors of Arvinas, Inc. Dr. Ratcliffe previously served on the boards of

13


directors of Unum Therapeutics, Inc., Edge Therapeutics, Inc., Array Biopharmaceuticals, Inc., Deciphera Pharmaceuticals, Inc. and Aptinyx Inc. Dr. Ratcliffe received an M.B.A. from the University of Michigan and an M.D. and Ph.D. in ImmunologyChemistry from theBrown University and a B.S. with Honors in Chemistry from St. Stephens College of Cape Town, and heDelhi University. Dr. Sondhi completed his internal medicine training andher post-doctoral fellowship in ImmunologyBioorganic Chemistry at Groote Schuur Hospital and associated teaching hospitals in Cape Town, South Africa.Rockefeller University. We believe that Dr. RatcliffeSondhi is qualified to serve on our boardBoard of directorsDirectors due to his extensive experienceher leadership experiences in the venture capital industry, medical and scientific background and training, and leadership at various biopharmaceutical and biotechnology companies.

Thomas Woiwode, Ph.D. has served as a member of our board of directors since September 2018. Since 2002, Dr. Woiwode has served in various investment and operational roles at Versant Venture Management, LLC, a healthcare investment firm, including Managing Director since July 2014 and a Venture Partner from 2011 to 2014. From 2011 to 2013, Dr. Woiwode served as Chief Operating Officer of Okarios AG, a biopharmaceutical company. Previously, Dr. Woiwode co-founded EuroVentures, a wholly owned biotechnology incubator within Versant Venture Management, LLC, and in this role, served as the founding Chief Business Officer for three biotechnology portfolio companies. Prior to Versant, Dr. Woiwode served as a Research Scientist at XenoPort, Inc., a biotechnology company. Dr. Woiwode currently serves on the boards of directors of Gritstone Oncology, Inc., Adverum Biotechnologies, Inc. and Aligos Therapeutics, Inc., as well as several private companies. Dr. Woiwode previously served on the board of directors of Audentes Therapeutics, Inc. and Crispr Therapeutics AG, both public biotechnology companies. Dr. Woiwode received a B.A. in English and a B.S. in Chemistry from the University of California, Berkeley and a Ph.D. in Organic Chemistry as an NSF Fellow from Stanford University. We believe that Dr. Woiwode is qualified to serve on our board of directors due to his educational background, experience as a board member and senior executive of biotechnologylife science and pharmaceutical companies, and experience as an investor in new life sciences companies.industry.

Family Relationships

There are no familial relationships among any of our directors and executive officers.

Board Diversity Matrix

Our Board of Directors and each of the standing committees of our Board of Directors has diverse representation. In addition, on our Board of Directors there are three directors who hold medical doctorates, two directors who hold doctorates in scientific fields and four directors who hold a masters in business administration. The table below provides certain highlights of the composition of our Board of Directors as of the date of this Proxy Statement, as reported by our directors. Each of the categories listed in the table below has the meaning set forth in Nasdaq Rule 5605(f). The diversity matrix of our Board of Directors for the year ended December 31, 2022 is available in our proxy statement for the 2023 annual meeting of our stockholders, filed with the SEC on April 14, 2023.

Board Diversity Matrix (As of March 28, 2024)
Total Number of Directors  7  
  Female Male Did Not Disclose Gender / Demographic Information
Part I: Gender Identity      
Directors 2 4 1
Part II: Demographic Background      
African American or Black   1  
Asian   3  
White 1    
Did Not Disclose Demographic Background 1   1

12

Non-Employee Director Compensation

Non-Employee Director Compensation for 2023

For the year ended December 31, 2020,2023, our non-employee directors received the following compensation pursuant to a program adopted(as approved by our Board of Directors, which was paid quarterly in arrears and was pro-rated for partial quarters served:Directors):

Cash Compensation.The program provides Each non-employee director received an annual cash retainer of $35,000$40,000. Additionally, the Chair of our Board of Directors received an additional annual payment of $30,000; the Chair of our Audit, Compensation and Nominating and Governance Committees received an additional annual payment of $15,000, $10,000 and $8,000, respectively; and the members of our Audit, Compensation and Nominating and Governance Committees received an additional annual payment of $7,500, $5,000 and $4,000, respectively. Cash compensation was paid quarterly in arrears and was pro-rated for partial quarters served.

Equity Compensation. Each new, non-employee director who joined our Board of Directors received an initial option grant for the purchase of shares of our common stock of 48,000 options upon election to our Board of Directors, which vest in equal monthly installments for three years after the grant date, subject to the director’s continued service on our Board of Directors. On the date of the 2023 annual meeting of stockholders, each non-employee director who continued to serve on our Board of Directors immediately following such meeting received an option grant for the purchase of shares of our common stock of 24,000 options, which vest on the one-year anniversary after the grant date, subject to the director’s continued service on our Board of Directors. In addition, equity awards for non-employee directors will vest in full in the event that we are subject to a change in control or upon certain other events. Non-employee directors receive no other form of remuneration, perquisites or benefits, but are reimbursed for their reasonable travel expenses incurred in attending board and committee meetings.

The following table sets forth the compensation earned by or paid to our non-employee directors for services provided during the year ended December 31, 2023. Dr. Chou, our President and Chief Executive Officer, did not receive compensation for his service as a director during 2023.

  Fees Earned or  Option  All Other    
Name Paid in Cash ($)  Awards(3) ($)  Compensation ($)  Total ($) 
Maxine Gowen, Ph.D.  83,000   18,339       101,339 
Athena Countouriotis, M.D.  51,630   18,339       69,969 
Saqib Islam  47,500   18,339       65,839 
Michael Kamarck, Ph.D. (1)   22,000   16,479   13,854 (4)   52,333 
Sandip Kapadia  55,000   18,339       73,339 
Derrell Porter, M.D.  50,957   18,339       69,296 
Dolan Sondhi, Ph.D.  18,333   31,570       49,903 
Tom Woiwode, Ph.D. (2)   26,250   18,339       44,589 

(1)Dr. Kamarck’s position terminated as a result of his death on June 30, 2023.

(2)Dr. Woiwode resigned from our Board of Directors on July 26, 2023.

(3)The amounts reported in this column represent the aggregate grant date fair value of the stock options granted to our non-employee directors during the year ended December 31, 2023, as computed in accordance with Financial Accounting Standards Board Accounting Standards Codification (FASB ASC) Topic 718. The assumptions used in calculating the aggregate grant date fair value of the stock options reported in this column are set forth in Note 12 to our financial statements included in our Annual Report on Form 10-K for the year ended December 31, 2023. The amounts reported in this column reflect the accounting cost for these stock options, and do not correspond to the actual economic value that may be received by our directors from the stock options. For information regarding the number of stock options held by each non-employee director as of December 31, 2023, see the table below:

NameOption Awards
Maxine Gowen, Ph.D.126,378
Athena Countouriotis, M.D.98,754
Saqib Islam164,057
Michael Kamarck, Ph.D. (4)69,567
Sandip Kapadia145,828
Derrell Porter, M.D.81,836
Dolan Sondhi, Ph.D.48,000
Tom Woiwode, Ph.D.-

(4)Dr. Kamarck’s position terminated as a result of his death on June 30, 2023. The Board accelerated all 54,901 shares of his unvested options and the exercise deadline for all shares was automatically extended to June 30, 2024 pursuant to the 2020 Equity Incentive Plan. The fair value for the accelerated vesting of $13,854, in accordance with FASB ASC Topic 718, is included within the All Other Compensation column in the table above.

13

New Non-Employee Director Compensation Policy

In April 2024, our Board of Directors adopted a new written Non-Employee Director Compensation Policy (the Policy). The Policy covers the elements and amounts of compensation that our non-employee directors receive, as well as certain process and governance requirements that will remain in place through December 31, 2027. In particular, the Policy requires the Compensation Committee to annually retain a compensation consultant to conduct an analysis of non-employee director compensation for the purpose of setting future compensation. The analysis is based on a group of comparable companies, or the Director Compensation Peer Group, that the consultant selects pursuant to the parameters described below. The Compensation Committee will then review and approve the Director Compensation Peer Group, as recommended by the compensation consultant, as well as any resulting recommendations for director compensation.

The Policy requires that the Director Compensation Peer Group be determined on an annual basis, based on the recommendations of the compensation consultant, and shall be limited to companies with market capitalizations of 0.4 to 2.25 times that of our market capitalization, except that if our market capitalization is less than $250 million, the constituent companies may have a market capitalization of 0.333 to 3 times that of our market capitalization.

In accordance with the Policy, the Compensation Committee retained Pearl Meyer as its compensation consultant for the determination of our 2024 non-employee director compensation program. Pearl Meyer established a peer group of twenty publicly traded companies for the purpose of informing non-employee director compensation decisions. The peer group reflected companies with the following characteristics:

Publicly traded and listed on a major exchange;

Primary business operations in the biotechnology or pharmaceutical industry;

Completed an initial public offering prior to January 1, 2022;

Does not currently generate revenues from the sale of marketed products;

Market capitalization between $18 million and $166 million;

Total full-time employee count between 40 and 200; and

Annual operating expenses between $50 million and $200 million.

14

The following peer group was selected based on the above-mentioned criteria (the “2024 Director Compensation Peer Group”).

In the table below, (i) “Full Time Employees” was compiled using information from the peer group company’s Human Capital disclosures within the most recently filed Form 10-K as of the date of the analysis and (ii) “Last Twelve Months Operating Expenses” was compiled using information from the peer group company’s financial statements within the most recently filed Form 10-k’s and 10-Q’s as of the date of the analysis.

Company Market
Capitalization at
12/31/2023
(in millions)
  Full Time
Employees  
  Last Twelve Months
Operating
Expenses
(in millions)
 
Adverum Biotechnologies, Inc. $76   123  $135 
Aligos Therapeutics, Inc. $50   83  $101 
Assembly Biosciences, Inc. $54   68  $75 
Athira Pharma, Inc. $92   63  $119 
Bolt Biotherapeutics, Inc. $43   94  $85 
DURECT Corporation $18   79  $51 
Homology Medicines, Inc. $35   92  $126 
Ikena Oncology, Inc. $95   80  $83 
Instil Bio, Inc. $50   192  $188 
Kezar Life Sciences, Inc. $69   84  $104 
Kronos Bio, Inc. $73   97  $132 
MEI Pharma, Inc. $39   41  $69 
Molecular Templates, Inc. $20   111  $79 
NextCure, Inc. $32   99  $70 
Precision BioSciences, Inc. $45   198  $131 
Rallybio Corporation $90   41  $75 
Rezolute, Inc. $39   42  $62 
Synlogic, Inc. $35   72  $63 
Vincerx Pharma, Inc. $25   41  $52 
X4 Pharmaceuticals, Inc. $140   70  $108 

The Policy also includes the following limitations on the amounts of compensation that may be paid to non-employee Directors:

Continuing Directors. The total average annual compensation of all continuing non-employee directors for any calendar year shall not exceed the 62.5th percentile of total combined annual cash and equity non-employee director compensation of the Company’s Director Compensation Peer Group.

New Directors. Any new director’s total annual cash compensation shall not exceed the 62.5th percentile of the Company’s Director Compensation Peer Group. Each new director’s initial equity award shall not exceed two times the value of the annual award granted to continuing directors in that year.

Market Capitalization Limitation. If our market capitalization is below $100 million, measured as of the last day of the fiscal quarter immediately preceding the date on which the Board approves annual non-employee director compensation, the total average non-employee director compensation shall not exceed $125,000, excluding any initial equity award granted to new directors as described above.

Compensation for other service. Any compensation awarded to non-employee directors for service as an officer, employee or consultant of the Company shall be excluded from the calculation of total average annual director compensation.

Equity Awards to be granted by Value. Equity awards to non-employee directors shall be calculated and granted in terms of a designated value, and not in terms of a fixed number of shares. Value (for the purposes of determining the number shares that will be subject to an award) means the grant date fair value of the award determined in accordance with ASC 718.

Non-Employee Director Compensation for 2024

Pearl Meyer recommended, and after review and recommendation by our Compensation Committee, our Board of Directors approved the 2024 non-employee director compensation program based on the analysis of the Peer Group and application of the provisions of the Policy:

Cash Compensation. An annual cash retainer of $40,000 to each non-employee director. Additionally, the Chair of our Board of Directors receives an additional annual payment of $35,000;$30,000; the Chair of our Audit, Compensation and Nominating and Governance Committees receive an additional annual payment of $15,000, $10,000 and $8,000, respectively; and the members of our Audit, Compensation and Nominating and Governance Committees receive an additional annual payment of $7,500, $5,000 and $4,000, respectively. Cash compensation will be paid quarterly in arrears and will be pro-rated for partial quarters served.

15

Equity Compensation. Each new, non-employee director who joins our Board of Directors will receive an initial option grant for the purchase of 33,836 shares of our common stock with a value of $90,000 upon election to our Board of Directors. Equity awards for new directors will vest in equal monthly installments for three years after the grant date if the director has served continuously as a member of our Board of Directors through the applicable vesting date. On the date of each annual meeting of stockholders, each non-employee director who continues to serve on our Board of Directors immediately following such meeting will receive an option grant for the purchase of 16,918 shares of our common stock or such other amount as determined by our Boardwith a value of Directors. Equity awards$45,000. Annual equity grants for new directors will vest in equal monthly installments for three yearson the one-year anniversary after the grant date if the director has served continuously as a member of our boardBoard of directors through the applicable vesting date. Annual equity grants for directors will vest in equal monthly installments for one year after the grant date if the director has served continuously as a member of our board of directorsDirectors through the applicable vesting date. In addition, equity awards for non-employee directors will vest in full in the event that we are subject to a change in control or upon certain other events. Non-employee directors receive no other form of remuneration, perquisites, or benefits, but are reimbursed for their reasonable travel expenses incurred in attending board and committee meetings.

14


The following table sets forth the compensation earned by or paid to our non-employee directors for services provided during the year ended December 31, 2020. Dr. Goldsmith, our President and Chief Executive Officer, received no compensation for his service as a director during 2020.

Fees Earned or

Paid in

Option

Name

    

Cash($)

    

Awards($)(1)

    

Total($)

Carl L. Gordon, Ph.D., CFA (2)

$

$

$

Patrick Heron (3)

 

46,500

 

458,816

 

505,316

Saqib Islam

 

42,500

 

229,408

 

271,908

Sandip Kapadia

 

50,000

 

762,259

 

812,259

Liam Ratcliffe, M.D., Ph.D.

 

43,000

 

458,816

 

501,816

Tom Woiwode, Ph.D.

 

45,000

 

458,816

 

503,816

Tadataka Yamada, M.D.

 

74,000

 

458,816

 

532,816

Athena Contouriotis, M.D.

 

33,205

 

458,816

 

492,021


(1)The amounts reported in this column represent the aggregate grant date fair value of the stock options granted to our directors during the year ended December 31, 2020 as computed in accordance with Financial Accounting Standards Board Accounting Standards Codification (FASB ASC) Topic 718. The assumptions used in calculating the aggregate grant date fair value of the stock options reported in this column are set forth in Note 9 to our financial statements included in our Annual Report on Form 10-K for the year ended December 31, 2020. The amounts reported in this column reflect the accounting cost for these stock options, and do not correspond to the actual economic value that may be received by our directors from the stock options. For information regarding the number of stock options held by each non-employee director as of December 31, 2020, see the table below.

Option

Name

Awards

Carl L. Gordon, Ph.D., CFA

 

Patrick Heron

33,836

Saqib Islam

99,139

Sandip Kapadia

80,910

Liam Ratcliffe, M.D., Ph.D.

33,836

Tom Woiwode, Ph.D.

33,836

Tadataka Yamada, M.D.

33,836

Athena Contouriotis, M.D.

33,836


(2)Dr. Gordon resigned from our Board of Directors in February 2020.
(3)Mr. Heron’s term will expire upon our 2021 Annual Meeting.

OUR BOARD OF DIRECTORS RECOMMENDS A VOTE “FOR” THE ELECTION OF EACH OF THE NOMINATED CLASS I DIRECTORS.

16

15


PROPOSAL NO. 2


RATIFICATION OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Our Audit Committee has selected KPMG LLP as our principal independent registered public accounting firm to perform the audit of our financial statements for the fiscal year ending December 31, 2021.2024. KPMG LLP audited our financial statements for the fiscal years ended December 31, 20202023 and 2019.2022. We expect that representatives of KPMG LLP will be present at the Annual Meeting, will be able to make a statement if they so desire and will be available to respond to appropriate questions.

At the Annual Meeting, the stockholders are being asked to ratify the appointment of KPMG LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2021.2024. Although ratification by stockholders is not required by law, our Audit Committee is submitting the selection of KPMG LLP to our stockholders because we value our stockholders’ views on our independent registered public accounting firm and as a matter of good corporate governance. If this proposal does not receive the affirmative approval of a majority of the votes cast on the proposal, the Audit Committee would reconsider the appointment. Notwithstanding its selection and even if our stockholders ratify the selection, our Audit Committee, in its discretion, may appoint another independent registered public accounting firm at any time during the year if the Audit Committee believes that such a change would be in our best interests and the interests of our stockholders.

The following table presents fees for professional audit services rendered by KPMG LLP for the audit of our annual financial statements for the years ended December 31, 20202023 and 2019.2022.

Principal Accountant Fees and Services

Fees Billed Fiscal Year 2023  Fiscal Year 2022 
Audit fees (1)  $480,500  $490,000 
Audit-related fees (2)   -   - 
Tax fees (3)   56,000   - 
All other fees (4)   -   - 
Total fees $536,500  $490,000 

Fees Billed

    

Fiscal Year 2020

    

Fiscal Year 2019

Audit fees(1)

$

1,250,000

$

240,000

Audit-related fees(2)

 

 

Tax fees(3)

 

 

All other fees(4)

 

 

Total fees

$

1,250,000

$

240,000


(1)Audit fees” include fees for professional services provided by KPMG LLP in connection with the audit of our financial statements, review of our quarterly financial statements, and related services that are typically provided in connection with registration statements, including the registration statement for our initial public offering.statements. Included in the 2020 Audit fees for fiscal year 2023 are $875,000 and $25,000$62,500 of fees billed in connection with our initial public offeringregistration statements under Form S-3 and Form S-8. Included in 2020Audit fees for 2022 are $65,000 of fees in connection with registration statements under Form S-3 and follow-on offering in 2021, respectively.Form S-8.

(2)There were no Audit-related fees” feesfor fiscal years 20202023 and 2019.2022.

(3)Tax fees” include fees for tax consulting services provided by KPMG LLP related to the Company’s position for an Employee Retention Tax Credit. There were no Tax fees” feesfor fiscal years 2020 and 2019.year 2022.

(4)There were no other fees incurred forin fiscal years 20202023 or 2019.2022.

Policy on Audit Committee Pre-Approval of Audit and Permissible Non-Audit Services of Independent Registered Public Accounting Firm

Our Audit Committee generally pre-approves all audit and permissible non-audit services provided by the independent registered public accounting firm. These services may include audit services, audit-related services, tax services and other services. Pre-approval is detailed as to the particular service or category of services and is generally subject to a specific budget. The independent registered public accounting firm and management are required to periodically report to the Audit Committee regarding the extent of services provided by the independent registered public accounting firm in accordance with this pre-approval, and the fees for the services performed to date. Our Audit Committee may also pre-approve particularpre-approves services on a case-by-case basis. All of the services relating to the fees described in the table above were approved by our Audit Committee.

OUR BOARD OF DIRECTORS RECOMMENDS A VOTE “FOR” APPROVAL OF PROPOSAL NO. 2.

17

16


REPORT OF THE AUDIT COMMITTEE

The information contained in the following report of the Audit Committee is not considered to be “soliciting material,” “filed” or incorporated by reference in any past or future filing by us under the Securities Exchange Act of 1934, as amended, or the Securities Act of 1933, as amended, unless and only to the extent that we specifically incorporate it by reference.

The Audit Committee has reviewed and discussed with our management and KPMG LLP our audited financial statements as of and for the year ended December 31, 2020.2023. The Audit Committee has also discussed with KPMG LLP the matters required to be discussed by the applicable requirements of the Public Company Accounting Oversight Board (United States) and the U.S. Securities and Exchange Commission.

The Audit Committee has received and reviewed the written disclosures and the letter from KPMG LLP required by applicable requirements of the Public Company Accounting Oversight Board regarding the independent accountant’s communications with the Audit Committee concerning independence, and has discussed with KPMG LLP its independence.

Based on the review and discussions referred to above, the Audit Committee recommended to our Board of Directors that the audited financial statements as of and for the year ended December 31, 20202023 be included in our Annual Report on Form 10-K for the year ended December 31, 20202023 for filing with the U.S. Securities and Exchange Commission.

Submitted by the Audit Committee

Sandip Kapadia, Chair


Athena Countouriotis, M.D.
Saqib Islam

Patrick Heron

18

17


SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

The following table sets forth certain information with respect to the beneficial ownership of our common stock as of March 31, 2021,18, 2024, by:

each stockholder known by us to be the beneficial owner of more than 5% of our common stock;

each of our directors or director nominees;

each of our named executive officers; and

all of our directors and executive officers as a group.

Percentage ownership of our common stock is based on 53,977,48455,611,796 shares of our common stock outstanding on March 31, 2021.18, 2024. We have determined beneficial ownership in accordance with the rules of the SEC, and thus it represents sole or shared voting or investment power with respect to our securities, and the information is not necessarily indicative of beneficial ownership for any other purpose. Unless otherwise indicated below, to our knowledge, the persons and entities named in the table have sole voting and sole investment power with respect to all shares that they beneficially owned, subject to community property laws where applicable. We have deemed all shares of common stock subject to options or other convertible securities held by that person or entity that are currently exercisable or that will become exercisable within 60 days of March 31, 202118, 2024 to be outstanding and to be beneficially owned by the person or entity holding the option for the purpose of computing the percentage ownership of that person or entity but have not treated them as outstanding for the purpose of computing the percentage ownership of any other person or entity. Unless otherwise indicated, the address of each beneficial owner listed in the table below is c/o Passage Bio, Inc., One Commerce Square, 2005 Market Street, 39th Floor, Philadelphia, PA 19103.

Beneficial Ownership

 

Name of Beneficial Owner

    

Number

    

Percent

 

5% Stockholders

 

  

 

  

FMR LLC (1)

 

5,278,100

 

9.8

%

Frazier Life Sciences IX, L.P. (2)

 

5,009,219

 

9.3

%

LAV Prescience Limited (3)

 

2,827,328

 

5.2

%

OrbiMed and affiliated entities (4)

 

6,262,899

 

11.6

%

Versant Ventures and affiliated entities (5)

 

4,959,769

 

9.2

%

Directors and Named Executive Officers:

 

  

 

  

Bruce Goldsmith, Ph.D. (6)

 

1,922,270

 

3.4

%

Stephen Squinto, Ph.D. (7)

 

1,113,492

 

2.0

%

Jill M. Quigley (8)

 

495,514

 

*

%

Gary Romano M.D., Ph.D. (9)

 

378,893

 

*

%

Athena Countouriotis (10)

 

32,998

 

*

%

Maxine Gowen, Ph.D. (11)

 

2,820

 

*

%

Patrick Heron (12)

 

5,023,317

 

9.3

%

Saqib Islam (13)

 

66,454

 

*

%

Sandip Kapadia (14)

 

44,587

 

*

%

Derrell Porter, M.D.

 

 

*

%

Liam Ratcliffe, M.D., Ph.D. (15)

 

16,898

 

*

%

Tom Woiwode, Ph.D. (16)

 

4,973,867

 

9.2

%

Tadataka Yamada, M.D. (17)

 

670,247

 

1.2

%

All executive officers and directors as a group (15 persons) (18)

 

14,722,950

 

25.5

%


  Beneficial Ownership 
Name of Beneficial Owner Number  Percent 
5% Stockholders (#)         
OrbiMed and affiliated entities (1)   10,124,576   18.2%
Versant Ventures and affiliated entities (2)   4,959,769   8.9%
Directors and Named Executive Officers:        
William Chou, M.D. (3)   551,782   1.0%
Athena Countouriotis, M.D. (4)   93,654   *%
Maxine Gowen, Ph.D.  (5)   102,378   *%
Saqib Islam (6)   145,057   *%
Sandip Kapadia (7)   121,828   *%
Derrell Porter, M.D. (8)   56,896   *%
Dolan Sondhi, Ph.D.  (9)   12,000   *%
Edgar B. (Chip) Cale (10)   849,261   1.5%
Mark Forman, M.D., Ph.D. (11)   366,455   *%
Alex Fotopoulos (12)   874,998   1.6%
Simona King (13)   386,641   *%
All executive officers and directors as a group (10 persons) (14)   2,401,607   4.3%

*

*Represents beneficial ownership of less than one percent.

#Excludes holdings of Lynx1 Capital Management LP, which filed a Form 13G on March 29, 2024, reporting the acquisition of 4,845,871 shares our common stock after the date set forth above.

(1)Based solely on a Schedule 13G filed on February 8, 2021. Represents 5,278,100 shares of common stock held by FMR LLC. Abigail P. Johnson is a director, the Chairman and the Chief Executive Officer of FMR LLC.

18


Members of the Johnson family, including Abigail P. Johnson, are the predominant owners, directly or through trusts, of Series B voting common shares of FMR LLC, representing 49% of the voting power of FMR LLC. The Johnson family group and all other Series B shareholders have entered into a shareholders’ voting agreement under which all Series B voting common shares will be voted in accordance with the majority vote of Series B voting common shares. Accordingly, through their ownership of voting common shares and the execution of the shareholders’ voting agreement, members of the Johnson family may be deemed, under the Investment Company Act of 1940, to form a controlling group with respect to FMR LLC. Neither FMR LLC nor Abigail P. Johnson has the sole power to vote or direct the voting of the shares owned directly by the various investment companies registered under the Investment Company Act (“Fidelity Funds”) advised by Fidelity Management & Research Company LLC (“FMR Co. LLC”), a wholly owned subsidiary of FMR LLC, which power resides with the Fidelity Funds’ Boards of Trustees. FMR Co. LLC carries out the voting of the shares under written guidelines established by the Fidelity Funds’ Boards of Trustees. The address of FRM LLC is 245 Summer Street, Boston, Massachusetts 02210.
(2)Based solely on a Schedule 13D/A filed on January 27, 2021.June 29, 2023. Represents 5,009,219 shares of common stock held by Frazier Life Sciences IX, L.P. (“Frazier Life Sciences”), of which FHMLS IX, L.P. (“FHMLS L.P.”) is the general partner. FHMLS IX, L.L.C. (“FHMLS LLC”) is the general partner of FHMLS L.P. Patrick Heron, a member of our board of directors whose term is expiring at our 2021 Annual Meeting, and James N. Topper are the members of FHMLS LLC and therefore share voting and investment power over the shares held by Frazier Life Sciences. The address of Frazier Life Sciences is c/o Frazier Healthcare Partners, 601 Union Street, Suite 3200, Seattle, WA 98101.
(3)Based solely on a Schedule 13G filed on February 9, 2021. Represents (a) 2,417,328 shares of common stock held by LAV Prescience Limited (“LAV”) and (b) 410,000 shares of common stock held by LAV Biosciences Fund V sub A, L.P. (“FUNDVSUBA”). Yi Shi is the managing partner of LAV and FUNDVSUBA, and may be deemed to have shared voting and dispositive power over the shares held by LAV and FUNDVSUBA. The address for LAV is Unit 902-904, Two ChinaCem Central, 26 Des Voeux Road Central, Hong Kong.
(4)Based solely on a Schedule 13DA filed on January 28, 2021. Represents (a) 5,947,323(i) 8,034,000 shares of common stock held by OrbiMed Private Investments VII, LP or OPI VII,(OPI VII) and (b) 1,015,576(ii) 2,090,576 shares of common stock held by Worldwide Healthcare Trust Plc (“Worldwide”)PLC (WWH). OrbiMed Capital GP VII LLC (OrbiMed GP) is the general partner of OPI VII and OrbiMed Advisors LLC (OrbiMed Advisors) is the managing member of OrbiMed Capital GP VII LLC.GP. OrbiMed Capital LLC (“OrbiMed Capital”)(OrbiMed Capital) is the investment advisor of WWH. As a result, OrbiMed Capital has the power to Worldwide.direct the vote and disposition of the shares held by WWH and may be deemed directly or indirectly, including by reason of mutual affiliation, to be the beneficial owner of the shares held by WWH. OrbiMed Capital disclaims any beneficial ownership over the shares of the other Reporting Persons. Carl Gordon, Ph.D., Sven H. Borho and Jonathan T. SilversteinW. Carter Neild are members of each of OrbiMed Capital GP VII LLC. In addition,and OrbiMed Capital exercisesAdvisors and may be deemed to share voting and dispositive power over the shares held by Worldwide through a management committee comprised of Dr. Gordon, Mr. Borho and Mr. Silverstein. Each of such individuals disclaims beneficial ownership over the shares held by OPI VII and Worldwide.WWH. The address for each of the OrbiMed Advisors and OrbiMed Capital is 601 Lexington Avenue, 54th Floor, New York, NY 10022. The address for Worldwide is 25 Southamption Buildings, Holborn, London WC2A 1AL, United Kingdom.

(5)(2)Based solely on a Schedule 13D13D/A filed on March 13, 2020.November 9, 2023. Represents (i) 4,026,417 shares of common stock beneficially owned by Versant Venture Capital VI, L.P. (“VVC VI”),(VVC VI) and (ii) 933,352 shares of common stock beneficially owned by Versant Vantage I, L.P. (“VV I”)(VV I). Versant Ventures VI GP, L.P. (“VV(VV VI GP”)GP) is the general partner of VVC VI, and Versant Ventures VI GP-GP, LLC (“VV(VV VI GP-GP”)GP-GP) is the general partner of VV VI GP. Each of Bradley J. Bolzon, Jerel C. Davis, Kirk G. Nielsen, Clare Ozawa, Robin L. Praeger and Tom Woiwode Ph.D., as managing members of VV VI GP-GP, may be deemed to share voting and dispositive power over the shares held by VVC VI. Versant Vantage I GP, L.P. (“VV(VV I GP”)GP) is the general partner of VV I, and Versant Vantage I GP-GP, LLC (“VV(VV I GP-GP”)GP-GP) is the general partner of VV I GP. Each of Bradley J. Bolzon, Jerel C. Davis, Clare Ozawa, Robin L. Praeger and Dr. Woiwode, as managing members of VV I GP-GP,GP-GP, may be deemed to share voting and dispositive power over the shares held by VV I. Dr. Woiwode is a Managing Director at Versant Ventures and a member of our board of directors, and may be deemed to have voting or dispositive power with respect to any of the above referenced shares and disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein. All indirect holders of the above referenced shares disclaim beneficial ownership of all applicable shares except to the extent of their respective pecuniary interest therein. The address for VVC VI and VV I is One Sansome Street, Suite 3630,1650, San Francisco, CA 94104.

19

(6)(3)Represents (i) 2,488 shares of common stock and (ii) 1,919,782551,782 shares underlying options to purchase common stock that are exercisable within 60 days of March 31, 2021.18, 2024.

19


(7)(4)Represents (i) 668,57518,900 shares of common stock and (ii) 444,91774,754 shares underlying options to purchase common stock that are exercisable within 60 days of March 31, 2021. Dr. Squinto is a venture partner of OrbiMed Advisors, which is the managing member of OrbiMed Capital GP VII, LLC, which is the general partner of OPI VII. Dr. Squinto does not hold voting or dispositive power over the shares held by OPI VII. See footnote 4 above.18, 2024.

(8)(5)Represents (i) 295,284 shares of common stock held directly by Ms. Quigley, of which 116,244 shares are unvested and subject to repurchase by us if Ms. Quigley ceases to provide service to us prior to the vesting of the shares, (ii) 1,000 shares of common stock held indirectly by Ms. Quigley for which she is deemed to be the beneficial owner, (iii) 187,042102,378 shares underlying options to purchase common stock that are exercisable within 60 days of March 31, 2021, and (iv) 12,18818, 2024.

(6)Represents (i) 5,000 shares underlying options to purchaseof common stock held indirectly by Ms. Quigley for which she is deemed to be the beneficial owner that are exercisable within 60 days of March 31, 2021.
(9)Represents 378,893and (ii) 140,057 shares underlying options to purchase common stock that are exercisable within 60 days of March 31, 2021.18, 2024.

(10)(7)Represents (i) 18,900 shares of common stock and (ii) 14,098121,828 shares underlying options to purchase common stock that are exercisable within 60 days of March 31, 2021.18, 2024.

(11)(8)Represents (i) zero shares of common stock and (ii) 2,82056,896 shares underlying options to purchase common stock that are exercisable within 60 days of March 31, 2021.18, 2024.

(12)(9)Represents (i) 14,09812,000 shares underlying options to purchase common stock that are exercisable within 60 days of March 31, 2021, (ii) 5,009,219 shares of common stock held by Frazier Life Sciences, of which FHMLS L.P. is the general partner. FHMLS LLC is the general partner of FHMLS L.P. Mr. Heron, a member of our board of directors whose term is expiring at our 2021 Annual Meeting, and James N. Topper are the members of FHMLS LLC and therefore share voting and investment power over the shares held by Frazier Life Sciences. See footnote 2 above.18, 2024.

(13)(10)Represents (i) 5,00049,495 shares of common stock and (ii) 61,454799,796 shares underlying options to purchase common stock that are exercisable within 60 days of March 31, 2021.18, 2024.

(14)(11)Represents (i) 5,00048,631 shares of common stock and (ii) 39,587317,824 shares underlying options to purchase common stock that are exercisable within 60 days of March 31, 2021.18, 2024.
(15)(12)Represents (i) 2,80078,693 shares of common stock and (ii) 14,098796,305 shares underlying options to purchase common stock that are exercisable within 60 days of March 31, 2021.18, 2024.

(16)(13)Represents (i) 14,09878,100 shares of common stock and (ii) 308,541 shares underlying options to purchase common stock that are exercisable within 60 days of March 31, 2020, (ii) 4,026,41718, 2024.

(14)Represents (i) 150,492 shares of common stock beneficially owned by VVC VI, and (iii) 933,352 shares of common stock beneficially owned by VV I. Dr. Woiwode, as a managing member of VV VI GP-GP and VV I GP-GP, may be deemed to share voting and dispositive power over the shares held by VVC VI and VV I, respectively. Dr. Woiwode is a Managing Director at Versant Ventures and a member of our board of directors, and may be deemed to have voting or dispositive power with respect to any of the above referenced shares. Dr. Woiwode disclaims beneficial ownership of all applicable shares except to the extent of their respective pecuniary interest therein. See footnote 5 above.
(17)Represents (i) 496,149 shares of common stock held directly by Dr. Yamada, (ii) 160,000 shares of common stock held by Dr. Yamada’s family trust and (iii) 14,0982,251,115 shares underlying options to purchase common stock that are exercisable within 60 days of March 31, 2021. Dr. Yamada,18, 2024, by our directors and executive officers, including our Chief Financial Officer who is not a venture partner of Frazier Life Sciences, does not have voting or dispositive power over thenamed executive officer. The total shares held by Frazier Life Sciences.
(18)Represents (i) 10,967,489exclude shares of common stock of which 116,244 shares are unvested and subject to repurchase by us if the holders cease to provide service to us prior to the vesting of the shares and (ii) 3,755,461 shares underlying options to purchase common stock that are exercisable within 60 days of March 31, 2021.18, 2024, by our former Chief Technology Officer and former Chief Financial Officer, as their employment with the Company was terminated as of July 28, 2023.

20

20


TableDELINQUENT SECTION 16(A) REPORTS

Section 16(a) of Contentsthe Exchange Act requires our directors, executive officers, and any persons who own more than 10% of our common stock to file initial reports of ownership and reports of changes in ownership with the SEC. Based solely on our review of the forms filed with the SEC and written representations from the directors and executive officers, we believe that all Section 16(a) filing requirements were timely met in the fiscal year ended December 31, 2023, with the exception of Forms 4 filed on April 5, 2023, on behalf of each of Mr. Fotopoulos, Dr. Chou, Ms. King, Dr. Forman, and Mr. Cale, which were each filed 13 business days late due to administrative error. In addition, the Form 4 filed on February 13, 2024, on behalf of Dr. Forman, included stock options and restricted stock units granted in fiscal years 2021 and 2022, which were inadvertently excluded due to administrative error from Dr. Forman’s Form 3 filed on April 8, 2022.

21

EXECUTIVE OFFICERS

The following table provides information regarding our executive officers as of March 31, 2021:28, 2024:

Name

Age

Position(s)

Name

William Chou, M.D.

Age

51

Position(s)

Bruce Goldsmith, Ph.D.

55

President, Chief Executive Officer President and Director

Jill M. Quigley

Kathleen Borthwick

46

48

Chief Operating Officer

Richard S. Morris

47

Chief Financial Officer

Eliseo Oreste Salinas, M.D.

65

Chief Research and Development Officer

Gary Romano, M.D., Ph.D.

60

Chief Medical Officer

Alex Fotopoulos

52

Chief Technical Officer

Edgar B. (Chip) Cale

57

60

General Counsel and Corporate Secretary

Mark Forman, M.D., Ph.D.

60Chief Medical Officer

Bruce A. Goldsmith, Ph.D.William Chou, M.D. has served as our President and Chief Executive Officer and President and as a member of our boardBoard of directorsDirectors since January 2020.October 2022. Dr. Goldsmith’sChou’s biographical information is set forth above under the heading “Proposal No. 1 Election of Class I Directors – Nominees to the Board of Directors.”Continuing Directors”.

Jill M. Quigley has served as our Chief Operating Officer since November 2018. From January 2017 to November 2018, Ms. Quigley served as Chief Executive Officer of Nutrinia Ltd., a pharmaceutical company focused on the treatment of rare conditions of the gastrointestinal tract. From July 2012 to December 2016, Ms. Quigley served as Senior Counsel of NPS Pharmaceuticals, a biotechnology company focused on developing treatments for rare diseases, which was acquired by Shire plc in March 2015. From 2011 to 2012, Ms. Quigley served as Corporate Counsel for Pharmasset, Inc., a pharmaceutical company. Ms. Quigley currently serves on the board of directors of Terns Pharmaceuticals, Inc., a biopharmaceutical company. Ms. Quigley began her career as an associate with the law firm of Dechert LLP and later served as Assistant Corporate Counsel for Integra LifeSciences Holdings Corporation. Ms. Quigley received a B.A. in Communications, Legal Institutions, Economics & Government (CLEG) from American University and a J.D. from Rutgers School of Law.

Richard S. Morris Kathleen Borthwickhas served as our Chief Financial Officer since October 2019. From November 2017 to July 2019, Mr. MorrisMarch 1, 2024. Ms. Borthwick served as Executiveour Senior Vice President and Interim Chief Financial Officer from July 2023 to March 2024 and as our Vice President of Context Therapeutics, LLC, a biopharmaceutical company.Finance from November 2021 to July 2023. From May 2014June 1997 to December 2016, Mr. Morris served as Chief Financial Officer of Vitae Pharmaceuticals, Inc., a biopharmaceutical company. Prior to that, Mr. MorrisOctober 2021, Ms. Borthwick served in various leadership roles of increasing responsibility at ViroPharma Incorporated, including as Vice President, Financial Planning and Strategic Analysis from 2012 to 2014; Vice President, Chief Accounting Officer from 2008 to 2012; Controller and Chief Accounting Officer from 2008 to 2011 and Controller from 2005 to 2008. Prior to joining ViroPharma, Mr. MorrisJohnson & Johnson Services, Inc. During her tenure at Johnson & Johnson, she worked for KPMG LLP in its Healthcare Assurance practice. Mr. Morris received a B.S.Finance in Accounting from Saint Joseph’s University and has been a CPA since 1999.

Eliseo Oreste Salinas, M.D. has served as our Chief Research and Development Officer since March 2021. Dr. Salinas served in various leadership roles at Acadia Pharmaceuticals, a biopharmaceutical company, including as Chief Scientific Officer, Senior Vice President, Head of External Innovation from August 2020 to March 2021 and Chief Scientific Officer, Senior Vice President, Head of Translational Research & External Innovation from September 2018 to August 2020. From June 2018 to September 2018, Dr. Salinas served as Chief Medical Officer for New World Laboratories. From August 2017 to May 2018, Dr. Salinas worked as a pharmaceutical consultant. From June 2015 to July 2017, Dr. Salinas served as Presidentsupport of Research & Development, Manufacturing, Business Development, Treasury and commercial operations for Turing Pharmaceuticals, which included serving as Interim Chief Executive Officer from April 2017 to July 2017. Prior to that, Dr. Salinas servedglobal Pharmaceutical and Medical Technology business segments. Ms. Borthwick earned her B.S. in various consultingEconomics with concentrations in Accounting and other leadership rolesHealth Care Management at Relmada Therapeutics, Stem Cells Inc., Elan Pharmaceuticals, Adolor Corporation, ViroChem Pharma Inc, Shire PLC, Wyeth Research, CR&Dthe Wharton School of University of Pennsylvania, and Synthelabo Recherche. Dr. Salinas received an M.D.her M.B.A. from the University of Buenos Aires, Argentina, completed his residency in Psychiatry at the Clinique des Maladies Mentales et de l'Encéphale, Paris, and obtained a Master of Science degree in Pharmacology from the Université Pierre et Marie Curie, Académie de Paris.

Gary Romano, M.D., Ph.D. has served as our Chief Medical Officer since September 2019. Prior to that, Dr. Romano worked at Janssen Global Services, LLC, a pharmaceutical company, where he served as Head of Development,

21


Alzheimer’s Disease / Neurology from May 2013 to September 2019 and as Head, Neuroscience Biomarkers from 2009 to 2013. Prior to Janssen, Dr. Romano served in various senior leadership roles at Johnson & Johnson, a healthcare company, and Merck & Co., Inc, a global biopharmaceutical company. Dr. Romano has held an adjunct clinical faculty position in the Department of Neurology at the Lewis Katz School of Medicine at Temple University since January 2017. Dr. Romano received a B.S. in Biology from Trinity College, a Ph.D. in Molecular Neuroscience from Rockefeller University and an M.D. from Johns Hopkin’s School of Medicine, and he completed his post-graduate training in Neurology at the University of Pennsylvania.

Alex Fotopoulos has served as our Chief Technical Officer since July 2019. From November 2017 to July 2019, Mr. Fotopoulos served as Senior Vice President, Technical Operations, Gene Therapy of Ultragenyx Pharmaceutical Inc., a biopharmaceutical company. From May 2016 to November 2017, Mr. Fotopoulos served as Senior Vice President, Technical Operations of Dimension Therapeutics, Inc., a biotechnology company, acquired by Ultragenyx Pharmaceutical Inc., focusing on the development of gene therapy for rare diseases associated with the liver and caused by genetic mutations. From August 2011 to May 2016, Mr. Fotopoulos served in various senior leadership roles at Momenta Pharmaceuticals, Inc., a biotechnology company, including Vice President, Technical Operations and Senior Director, Technical Operations. Prior to that, Mr. Fotopoulos served for 18 years in various senior leadership roles at Biogen, Inc., a biotechnology company, including Senior Director, Global Manufacturing Engineering and Director, Global Engineering Technology. Mr. Fotopoulos received a Diploma in Chemical Engineering at the National Technical University of Athens, Greece, a M.Sc. in Chemical Engineering from Tufts University, and a M.B.A. in General Management from the F.W. Olin GraduateTuck School of Business at BabsonDartmouth College.

Edgar B. (Chip) Cale has served as our General Counsel since September 2019 and Corporate Secretary since December 2019. From June to October 2022, Mr. Cale also served as our interim Chief Executive Officer. From June 1998 to July 2019, Mr. Cale served in various senior leadership roles at GlaxoSmithKline plc, a multinational pharmaceutical company, includingmost recently as Senior Vice President, Legal Corporate Functions;Functions. Prior to this Mr. Cale also served as Vice President, Associate General Counsel, Legal Operations, WWBD;and head of legal support for GSK’s worldwide business development and Vice President, General Counsel of GSK Vaccines; and Assistant General Counsel.Vaccines. Prior to that, Mr. Cale served as a corporate and securities lawyer supporting emerging growth companies in the life sciencesciences and technology industries at Venture Law Group LLP and Brobeck, Phleger & Harrison LLP. Mr. Cale received a B.A. in Biology from the University of Pennsylvania and a J.D. from the University of California, Berkeley.

Mark Forman, M.D., Ph.D. has served as our Chief Medical Officer since July 2021. Dr. Forman is a neuropathologist and neuroscientist with deep expertise in development of drugs for neurological and psychiatric disorders. From January 2021 to July 2021, Dr. Forman led the Alzheimer’s Drug Discovery Foundation (ADDF) Scientific Affairs team that oversees their drug discovery and drug development portfolio. Prior to joining the ADDF, Dr. Forman was Vice President at Acadia Pharmaceuticals from March 2019 to January 2021, where he was Head of Translational Medicine, responsible for preclinical and early clinical development and contributed to the development of pimavanserin for the treatment of hallucinations and delusions associated with dementia-related psychosis and trofinetide for Rett syndrome. Dr. Forman also spent 12 years at Merck where he was Executive Director and Neuroscience Lead in Translational Medicine, responsible for the neuroscience portfolio in early clinical development and multiple New Drug Applications. Dr. Forman has been a member of scientific advisory board for Biomarkers and Treat FTD at the Association for Frontotemporal Dementia since 2012. Dr. Forman received his Ph.D. at Rockefeller University, M.D. at Duke University and a B.S. at Yale University.

22

22


EXECUTIVE COMPENSATION

The following tables and accompanying narrative disclosure set forth information about the compensation provided to certain of our executive officers during the years ended December 31, 20192023 and 2020.2022. These executive officers, who includewhich consist of our principal executive officer, and theour two most highly-compensated executive officers (other than our principal executive officer) who were serving as executive officers at the end of the fiscal year ended December 31, 2020,2023, and two individuals for whom disclosure would have been required but for the fact that such individuals were not serving as executive officers as of December 31, 2023, were:

Bruce Goldsmith, Ph.D.William Chou, M.D., our President and Chief Executive Officer and President;Officer;

Stephen Squinto, Ph.D.,Edgar B. (Chip) Cale, our former interim Chief Executive Officer until January 2020General Counsel and former Acting Head of Research and Development;Company Secretary;

Jill Quigley,Mark Forman, M.D., Ph.D, our Chief OperatingMedical Officer; and

Gary Romano, M.D.Alex Fotopoulos, Ph.D., our former Chief MedicalTechnical Officer; and

Simona King, our former Chief Financial Officer.

We refer to these individuals as our “named executive officers.”

23

Summary Compensation Table

The following table presents summary information regarding the total compensation for services rendered in all capacities that was awarded to and earned by our named executive officers during the years ended December 31, 20202023 and 2019:2022:

           Non-equity             
           incentive plan  Option     All other    
        Bonus  compensation  awards  Stock Awards  compensation  Total 
Name and principal position Year  Salary ($)  ($)  ($)(5)   ($)(6)    ($)  ($)  ($) 
William Chou, M.D.  2023   599,231   -   330,000   502,815   -   16,500(8)   1,448,545 
President, Chief Executive Officer and Director  2022   111,538(1)   200,000(3)   72,000   900,663   -   11,887(9)   1,296,088 
Edgar B. (Chip) Cale  2023   419,952   200,000(4)   168,240   145,034   -   16,500(8)   949,726 
General Counsel and Corporate Secretary  2022   508,125(2)   -   149,351   682,911   66,500(7)   16,882(8)   1,423,769 
Mark Forman, M.D., Ph.D.  2023   462,188   200,000(4)   187,626   145,034   -   16,500(8)   1,011,348 
Chief Medical Officer                                
Alex Fotopoulos  2023   315,803   -   -   145,034   -   840,134(10)   1,300,971 
Former Chief Technical Officer  2022   463,479   -   176,878   914,648   66,500(7)   13,611(8)   1,635,116 
Simona King  2023   304,477   -   -   116,027   -   691,854(11)   1,112,358 
Former Chief Financial Officer  2022   454,797   -   162,000   829,183   131,750(7)   16,115(8)   1,593,845 

    

    

    

    

Non-equity

    

    

    

incentive plan

Option

All other

Bonus

compensation

awards

compensation

Total

Name and principal position

Year

Salary ($)

($)

($) (4)

($) (5)

($)

($)

Bruce Goldsmith, Ph.D.

 

2020

 

450,000

(1)

258,750

 

15,985,702

 

12,623

(6)

16,707,075

Chief Executive Officer and President

Stephen Squinto, Ph.D.

 

2020

 

246,000

 

 

 

2,977,939

 

540,993

(7)

3,764,932

Former Interim Chief Executive Officer and former Acting Head of Research and Development

 

2019

 

225,000

 

 

127,406

 

1,787,945

 

 

2,140,351

Jill Quigley

 

2020

 

431,800

 

202,950

 

3,390,497

 

362,922

(8)

4,388,169

Chief Operating Officer

Gary Romano, M.D., Ph.D.

 

2020

 

416,300

 

107,419

(3)

191,500

 

1,468,843

 

14,250

(9)

2,198,312

Chief Medical Officer

 

2019

 

111,058

(2)

 

49,143

 

1,859,880

 

2,252

(10)

2,022,333


1)(1)Dr. Goldsmith’sChou’s employment with us commenced on January 28, 2020.October 10, 2022. The salary reported reflects the pro rata portion of Dr. Goldsmith’sChou’s 2022 annual salary of $500,000$580,000 earned during 20202022 from the commencement of his employment through December 31, 2020.2022.

2)Dr. Romano’s employment with us commenced on September 9, 2019. The(2)Mr. Cale’s salary reported reflects the pro rata portion of Dr. Romano’s annualhis base salary of $385,000 earned during 2019 from commencement of his employment through December 31, 2019.$403,650 and includes additional compensation received for services provided as our Interim Chief Executive Officer in 2022.

3)(3)The amount reflects a discretionarysign-on bonus granted to Dr. RomanoChou in 2020.2022 to compensate for his foregone bonus from his previous employer.

4)(4)The amount reflects a retention bonus of $200,000 which was earned on December 31, 2023.
(5)For additional information regarding the non-equity incentive plan compensation, see the section entitled "Non-Equity“Non-Equity Incentive Plan Compensation."

5)(6)Represents the grant date fair value of options awarded during the applicable year as computed in accordance with FASB ASC Topic 718. The assumptions used in calculating the grant date fair value of the stock options reported in the Options Award column are set forth in Note 912 to our financial statements included elsewhere in this prospectus.with our 2023 Annual Report under Form 10-K. Note that the amounts reported in this column reflect the aggregate accounting cost, under generally accepted accounting principles, for these awards and do not necessarily correspond to the actual economic value that may be received by each named executive officer from the options.

6)(7)Represents the grant date fair value of restricted stock units awarded during the applicable year as computed in accordance with FASB ASC Topic 718. The assumptions used in calculating the grant date fair value of the restricted stock units reported in the Restricted Stock Units column are set forth in Note 12 to our 2023 financial statements included with our 2023 Annual Report under Form 10-K. Note that the amounts reported in this column reflect the aggregate accounting cost, under generally accepted accounting principles, for these awards and do not necessarily correspond to the actual economic value that may be received by each named executive officer from the restricted stock units.

(8)Represents matching contributions under our 401(k) Plan and certain other de minimis perquisites.

(9)Represents a $12,623 matching contribution under our 401(k) Plan.

23


7)Represents loan forgiveness in the amount of $540,993. See “Certain relationships and related party transactions—Loans to executive officers.”
8)Represents a $14,250$4,387 matching contribution under our 401(k) Plan and loan forgiveness$7,500 for reimbursement of legal expenses incurred and reimbursed to Dr. Chou in connection with the amountreview of $324,672. See “Certain relationships and related party transactions—Loans to executive officers,” a $24,000 vehicle allowance.his employment agreement.

9)(10)Represents $20,000 of compensation provided for advisory services under the Fotopoulos Advisory Agreement (as defined below), a $14,250$16,661 matching contribution under our 401(k) Plan.Plan, $684,088 paid in connection with the Fotopoulos Separation Agreement (as defined below), including salary, severance, accelerated retention bonus payment, COBRA premiums, and $119,385 of accelerated equity compensation.

10)(11)Represents a $2,252$16,500 matching contribution under our 401(k) Plan.Plan and $666,650 paid in connection with the King Separation Agreement (as defined below), including salary, severance, accelerated retention bonus payment, COBRA premiums, and $8,704 of accelerated equity compensation.

24

Executive Compensation Overview

We endeavor to maintain sound compensation governance standards consistent with our executive compensation policies and practices. Our Compensation Committee regularly reviews all compensation components to ensure that they are consistent with our short-term and long-term goals, including base salary, bonus, benefits, equity incentives, and other perquisites, as well as severance arrangements, change-in-control benefits and other forms of executive officer compensation. In addition, the Compensation Committee also considers matters related to individual compensation, such as compensation for new executive hires, as well as high-level strategic issues, such as the efficacy of our compensation strategy, potential modifications to that strategy, and new trends, plans, or approaches to compensation, at various meetings throughout the year. When considering the total variable pay-mix for our executive officers, we seek to design and implement a competitive executive compensation program that combines both cash and incentive elements based on annual performance objectives and long-term equity elements that will be flexible and complementary to meet our compensation objectives. The Compensation Committee also has the authority to administer our equity-based plans, both directly and through delegated authority to the Chief Executive Officer.

Our Compensation Committee provides a recommendation on the compensation of our Chief Executive Officer to the Board of Directors and approves the compensation of our other executive officers.

In the fall of 2022, the Compensation Committee engaged Pearl Meyer to evaluate our executive compensation program and provide a market frame of reference for setting compensation for the 2023 fiscal year. In evaluating the total compensation of our executive officers, the Compensation Committee, with the assistance of Pearl Meyer, established a peer group of twenty publicly traded companies in the biopharmaceutical industry whose market capitalization, operating size, maturity of product development pipeline or area of therapeutic focus were similar to Passage Bio at that time. In the fall of 2023, Pearl Meyer again assisted the Compensation Committee for the evaluation of our executive compensation program for the 2024 fiscal year. As part of its advice, Pearl Meyer developed a new peer group of twenty-one publicly traded companies in the biopharmaceutical industry to evaluate our executive compensation program and provide a market frame of reference for setting compensation for the 2024 fiscal year, which accounted for the evolution of the Company between 2022 and 2023 and reflected the characteristics of the Company at that time. Pearl Meyer used this peer group to assist the Compensation Committee in conducting a competitive compensation assessment for our executive officers for the fiscal year ended December 31, 2023 and for fiscal year 2024 compensation planning.

25

Base Salary

Base salaries are reviewed annually and may be adjusted to realign salaries with market levels of compensation paid by our peer companies, after considering individual responsibilities and performance over the past year. In 2023, the base salary of our continuing officers increased by 3% to 6.5% to better align them with market practices.

Non-Equity Incentive Plan Compensation

Annual bonuses for our executive officers are based on the achievement of individual performance objectives and corporate performance objectives.

Annual bonuses forobjectives established by our executive officersBoard of Directors that are based on the achievement ofgoals related to research and development, regulatory, financial and other general corporate and individual performance objectives.goals. The 20202023 target bonus amounts, expressed as a percentage of annual base salary, for our named executive officers were 45%55% for Dr. Goldsmith, 40% for Ms. Quigley,Chou, and 40% for Mr. Cale, Dr. Romano.Forman, Mr. Fotopoulos, and Ms. King. In February 2024, based on the achievement of these corporate and personal performance objectives, our Board of Directors determined to award bonuses as reflected in the table above to Dr. Chou, Mr. Cale and Dr. Forman. Mr. Fotopoulos and Ms. King did not receive their target bonus as their employment with the Company was terminated effective on July 28, 2023.

2020

Retention Bonus

In order to retain the leadership and services of the executive team during a time of transition, the Committee provided retention bonuses that were payable subject to the executive’s employment through December 31, 2023, as reflected in the table above. Mr. Cale and Dr. Forman both earned and received the retention bonus. Mr. Fotopoulos and Ms. King received their retention bonus as part of their separation benefits in exchange for a release of claims.

Equity Awards

In 2023, the Company granted stock options to our named executive officers as a way to incentivize them and as a retention vehicle.

2023 Outstanding Equity Awards at Fiscal Year-End Table

The following table presents, for each of our named executive officers, information regarding outstanding stock options and restricted stock units held as of December 31, 2020.2023. Awards to date have been granted under our 2018 Equity Incentive Plan (2018 EIP), 2020 Equity Incentive Plan (2020 EIP) and 2021 Equity Inducement Plan (2021 EIP).

Option Awards

Number of

Number of

securities

securities

underlying

underlying

Option

Number of

Vesting

unexercised

unexercised

exercise

Option

shares of stock

Market value of

Grant

Commencement

options

options

price

expiration

that have not

shares that have

Name

    

date

    

Date

    

exercisable

    

unexercisable

    

($)

    

date

    

vested (#)

    

not vested ($)

Bruce Goldsmith

1/28/2020

(1) (3)

1/28/2020

 

1,919,782

 

11.00

 

1/28/2030

Steve Squinto

2/6/2019

(1)(4)

9/19/2018

 

 

1.02

 

2/6/2029

112,815

2,884,680

2/6/2019

(1)(4)

5/8/2019

 

 

1.02

 

2/6/2029

40,928

1,046,529

10/23/2019

(1) (5)

10/9/2018

 

225,305

 

8.07

 

10/23/2029

2/27/2020

(2) (6)

2/27/2020

 

185,776

 

18.00

 

2/27/2030

2/27/2020

(2) (7)

3/27/2020

 

9,398

 

24,438.00

18.00

 

2/27/2030

Jill Quigley

2/6/2019

(1) (8)

11/12/2018

 

7,772

 

7,152.00

1.02

 

2/6/2029

2/6/2019

(1) (9)

5/8/2019

 

40,542

 

47,888.00

1.02

 

2/6/2029

2/6/2019

(1) (10)

2/6/2019

 

 

 

1.02

 

2/6/2029

148,534

3,798,014

1/15/2020

(1) (11)

12/17/2019

 

15,509

 

46,539.00

11.00

 

1/15/2030

2/27/2020

(2) (12)

2/27/2020

 

 

211,001.00

18.00

 

2/27/2030

Gary Romano

10/23/2019

(1)(13)

8/20/2019

 

310,821

 

8.07

 

10/23/2029

1/15/2020

(1) (13)

12/17/2019

 

54,850

 

11.00

 

1/15/2030

2/27/2020

(2) (14)

2/27/2020

 

 

74,311.00

18.00

 

2/27/2030


1)Equity award was granted under our 2018 Equity Incentive Plan.26

       Option Awards Stock Awards
                     Market value 
         Securities Securities       Number of of shares or
         underlying underlying Option     shares or restricted restricted stock
       Vesting unexercised unexercised exercise Option   stock units units
  Grant Equity  Commencement options options price expiration Grant that have not that have
Name date Plan  date exercisable unexercisable ($) date date vested (#) not vested ($)
                      
William Chou, M.D. 10/10/2022 2020 EIP(1) 10/10/2022  64,020  155,480  1.32 10/10/2032      
  10/10/2022 2021 EIP(1) 10/10/2022  194,104  471,396  1.32 10/10/2032      
  3/15/2023 2020 EIP(2) 3/15/2023  114,115  494,500  1.08 3/15/2033      
Edgar B. (Chip) Cale 10/23/2019 2018 EIP(1) 9/23/2019  274,254  -  8.07 10/23/2029      
  2/27/2020 2020 EIP(1) 2/27/2020  95,575  4,156  18.00 2/27/2030      
  2/16/2021 2020 EIP(1) 2/15/2021  121,122  49,875  21.85 2/16/2031      
  2/10/2022 2020 EIP(2) 2/10/2022  48,583  57,417  4.52 2/10/2032      
  5/31/2022 2020 EIP(3) 5/31/2022  100,000  -  1.80 5/31/2032      
  6/13/2022 2020 EIP(4) 6/13/2022  53,000  53,000  2.29 6/13/2032      
    2020 EIP            11/10/2022  50,000(11)  50,500
  3/15/2023 2020 EIP(2) 3/15/2023  32,812  142,188  1.08 3/15/2033      
Mark Forman, M.D. 8/16/2021 2020 EIP(1) 7/30/2021  78,541  51,459  10.84 8/16/2031      
  2/10/2022 2020 EIP(2) 2/10/2022  11,458  13,542  4.52 2/10/2032      
    2020 EIP            2/10/2022  15,000(12)  15,150
  4/18/2022 2020 EIP(1) 4/18/2022  56,666  79,334  2.61 4/18/2032      
  6/13/2022 2020 EIP(4) 6/13/2022  68,000  68,000  2.29 6/13/2032      
    2020 EIP            11/10/2022  50,000(11)  50,500
  3/15/2023 2020 EIP(2) 3/15/2023  32,812  142,188  1.08 3/15/2033      
Alex Fotopoulos 10/23/2019 2018 EIP(5) 7/22/2019  310,821  -  8.07 10/23/2029      
  1/15/2020 2018 EIP(5) 12/17/2019  54,850  -  10.99 1/15/2030      
  2/27/2020 2020 EIP(5) 2/27/2020  71,214  3,097  18.00 2/27/2030      
  2/16/2021 2020 EIP(5) 2/15/2021  74,375  15,312  21.85 2/16/2031      
    2020 EIP            5/17/2021  25,000(13)  25,250
  2/10/2022 2020 EIP(5) 2/10/2022  75,120  23,902  4.52 2/10/2032      
  6/13/2022 2020 EIP(6) 6/13/2022  100,000  38,888  2.29 6/13/2032      
    2020 EIP            11/10/2022  50,000(11)  50,500
  3/15/2023 2020 EIP(7) 3/15/2023  32,812  25,521  1.08 3/15/2033      
Simona King 8/23/2021 2021 EIP(8) 8/23/2021  172,500  -  11.43 8/23/2031      
  2/10/2022 2020 EIP(8) 2/10/2022  59,625  -  4.52 2/10/2032      
  6/13/2022 2020 EIP(9) 6/13/2022  61,833  -  2.29 6/13/2032      
  3/15/2023 2020 EIP(10) 3/15/2023  14,583  -  1.08 3/15/2033      

2)Equity award was granted under our 2020 Equity Incentive Plan.27

3)(1)The option vests as to 25% of the total shares on January 28, 2021the first anniversary date of the grant date and then 2.0833% of the total shares vest monthly thereafter, with 100% of the total shares vested on January 28, 2024,the fourth anniversary of grant date subject to the reporting person’s provision of service to the issuerCompany on each vesting date.

(2)The option vests 2.0833% of the total shares monthly with 100% of the total shares vested on the fourth anniversary of the grant date, subject to the reporting person’s provision of service to the Company on each vesting date.

(3)The option vests 8.3333% of the total shares on June 30, 2022, and then 8.3333% of the total shares vest monthly thereafter, with 100% of the total shares vested on May 31, 2023, subject to the reporting person’s provision of service to the Company on each vesting date. The option provides for an early-exercise provision and is exercisable aswas provided in connection with Mr. Cale’s appointment to unvestedinterim Chief Executive Officer.

(4)The option vests 2.7778% of the total shares monthly with 100% of the total shares vested on the third anniversary of the grant date, subject to the issuer’s rightreporting person’s provision of repurchase.service to the Company on each vesting date.

4)Dr. Squinto early exercised these stock options in fiscal year 2019 at(5)Under the original exercise price of $1.02 per share and received a restricted stock award subject to our right of repurchase as to the unvested portion. The repurchase right lapses pursuant to the option’s vesting schedule, which is as follows: 50%terms of the shares underlyingoption agreement, the option vest on the six-month anniversary of the vesting commencement date and the remaining 50% of the shares underlying the option vest in equal monthly installments over 36 months thereafter, subject to the executive’s continued service to us.
5)The option is subject to an early exercise provision and is immediately exercisable for restricted shares. Restricted shares acquired upon the early exercise of options are subject to repurchase by us at the original exercise price, which repurchase right

24


lapses pursuant to the option’s vesting schedule, which is as follows: 1/36th of the shares underlying the option vest on the one-month anniversary of the vesting commencement date and an additional 1/36th vests monthly thereafter, subject to the executive’s continued service to us.
6)The option vestsvested as to 25% of the total shares on February 27, 2021,the first anniversary date of the grant date and then 2.0833% of the total shares vest monthly thereafter, with 100% of the total shares vested on February 27, 2024, subjectthe fourth anniversary of grant date. In connection with the Advisory Agreement and the Fotopoulos Separation Agreement, all unvested options will continue to vest through the reporting person’s provisionterm of servicethe Advisory Agreement and 80,191 unvested options were cancelled. In addition, the separation agreement extended the deadline to exercise the issuer on each vesting date.unexercised vested shares to twelve months following the termination or expiration of the Advisory Term (as defined below).

7)The(6)Under the original terms of the option vest as to 2.778%agreement, the option vested 2.7778% of the total shares monthly commencing March 27, 2020, with 100% of the total shares vested on February 27, 2023, subjectthe third anniversary of the grant date. In connection with the Advisory Agreement and the Fotopoulos Separation Agreement, all unvested options continued to vest through the reporting person’s provisionterm of servicethe Advisory Agreement and 61,112 unvested options were cancelled. In addition, the separation agreement extended the deadline to exercise the issuer on each vesting date.unexercised vested shares to twelve months following the termination or expiration of the Advisory Term.

8)The(7)Under the original terms of the option agreement, the option vested 2.0833% of the total shares monthly with 100% of the total shares vested on the fourth anniversary of the grant date. In connection with the Advisory Agreement and the Fotopoulos Separation Agreement, all unvested options continued to vest through the term of the Advisory Agreement and 116,667 unvested options were cancelled. In addition, the separation agreement extended the deadline to exercise the unexercised vested shares to twelve months following the termination or expiration of the Advisory Term.

(8)Under the original terms of the option agreement, the option vested as to 25% of the total shares on November 12, 2019the first anniversary date of the grant date and then 2.0833% of the total shares vest monthly thereafter, with 100% of the total shares vested on November 12, 2022,the fourth anniversary of grant date. In connection with the King Separation Agreement, 3,313 shares subject to this option were accelerated as of July 28, 2023 and 286,875 unvested options were cancelled. In addition, the reporting person’s provision of serviceseparation agreement extended the deadline to exercise the issuer on each vesting date.unexercised vested shares to July 28, 2024.

9)The(9)Under the original terms of the option vests as to 25%agreement, the option vested 2.7778% of the total shares monthly with 100% of the total shares vested on May 8, 2020the third anniversary of the grant date. In connection with the King Separation Agreement, 4,417 shares subject to this option were accelerated as of July 28, 2023 and then97,167 unvested options were cancelled. In addition, the separation agreement extended the deadline to exercise the unexercised vested shares to July 28, 2024.

(10)Under the original terms of the option agreement, the option vested 2.0833% of the total shares monthly with 100% of the total shares vested on the fourth anniversary of the grant date. In connection with the King Separation Agreement, 2,917 shares subject to this option were accelerated as of July 28, 2023 and 125,417 unvested options were cancelled. In addition, the separation agreement extended the deadline to exercise the unexercised vested shares to July 28, 2024.
(11)Represents restricted stock units, which vested 100% on December 31, 2023, and were considered outstanding until settlement on January 2, 2024.
(12)Represents restricted stock units, which 33.3333% vests on February 10, 2024, and the remaining 66.6667% vest monthlyon February 10, 2025.
(13)Represents restricted stock units, which under the original agreement, 25% vests on June 15, 2022, and an additional 25% vesting annually thereafter, with 100% of the total shares vested on May 8, 2023 subject toJune 15, 2025. In connection with the reporting person’s provision of service toAdvisory Agreement and the issuer on each vesting date.
10)Ms. Quigley early exercised these stock options in fiscal year 2019 at the original exercise price of $1.02 per share and received aFotopoulos Separation Agreement, all unvested restricted stock award subjectunits continued to our right of repurchase as to the unvested portion. The repurchase right lapsesvest pursuant to their terms for so long as Mr. Fotopoulos provides services under the option’s vesting schedule, whichAdvisory Agreement and will become fully vested as of July 28, 2024, so long as the Advisory Agreement is as follows: 25% of the total shares will vest on February 6, 2020 and then 2.0833% of the total shares vest monthly thereafter, with 100% of the total shares vested on February 6, 2023 subjectnot terminated prior to the reporting person’s provision of service to the issuer on each vesting date.July 28, 2024.

11)The option vests as to 25% of the total shares on December 17, 2020 and then 2.0833% of the total shares vest monthly thereafter, with 100% of the total shares vested on December 17, 2023, subject to the reporting person’s provision of service to the issuer on each vesting date. The option provides for an early-exercise provision and is exercisable as to unvested shares, subject to the issuer’s right of repurchase.28
12)The option vests as to 25% of the total shares on February 27, 2021, and then 2.0833% of the total shares vest monthly thereafter, with 100% of the total shares vested on February 27, 2024, subject to the reporting person’s provision of service to the issuer on each vesting date.
13)The option is subject to an early exercise provision and is immediately exercisable for restricted shares. Restricted shares acquired upon the early exercise of options are subject to repurchase by us at the original exercise price, which repurchase right lapses pursuant to the option’s vesting schedule, which is as follows: 1/4th of the shares underlying the option vest on the one-year anniversary of the vesting commencement date and an additional 1/48th vests monthly thereafter, subject to the executive’s continued service to us.
14)The option vests as to 25% of the total shares on February 27, 2021, and then 2.0833% of the total shares vest monthly thereafter, with 100% of the total shares vested on February 27, 2024, subject to the reporting person’s provision of service to the issuer on each vesting date.

25


Employment Agreements – Transition and Separation Agreements

We have entered into written employment agreements with certain senior management personnel, includingeach of our named executive officers. Each of these agreements provides for at-will employment and includes each officer’s base salary, a discretionary annual incentive bonus opportunity that may be based on individual and company performance and standard employee benefit plan participation. These agreements also provide for severance benefits upon termination of employment or a change in control of our company.

Dr. Squinto resigned from his position as our Interim Chief Executive Officer and President effective January 28, 2020 and was appointed Acting Head of Research and Development. Dr. Squinto resigned from our Board of Directors and as our Acting Head of Research and Development on February 18, 2021. We had In July 2023, the Company entered into a consulting agreementTransition and Separation Agreements with Dr. Squinto pursuant to which he received an annual fee at a rate of $309,000 per year through April 1, 2020,Mr. Fotopoulos and $225,000 per year starting April 1, 2020, in each case payable quarterly in arrears. In addition, in the event of the earlier to occur of (i) Dr. Squinto’s continued service on our board through the second annual meeting of our stockholders held following the effective date of this registration statement and (ii) a change in control, each of Dr. Squinto’s then-outstanding unvested equity awards would accelerate and become fully vested upon such applicable event, subject to Dr. Squinto’s execution and non-revocation of a release of claims in our favor. Upon Dr. Squinto’s resignation from our Board of Directors and as our Acting Head of Research and Development, we accelerated vesting of Dr. Squinto’s outstanding stock options and restricted stock that were scheduled to accelerate on the date of our 2022 annual general meeting of stockholders and Dr. Squinto entered into a customary release of claims in our favor.Ms. King.

William Chou, M.D.

Effective January 28, 2020, Bruce Goldsmith, Ph.D.as of October 10, 2022, William Chou, M.D. was appointed as our Chief Executive Officer and President, and a member of our boardBoard of directors.Directors. Dr. Goldsmith will receive anChou’s employment agreement provides for at-will employment and included his initial base salary, discretionary annual salaryincentive bonus opportunity, certain initial equity incentive awards and standard employee benefit plan participation. The details of $500,000 and be eligible for an annual target bonus equal to 45% of his annual salary. In addition, Dr. Goldsmith was granted an option to purchase 1,919,782 shares, with 25% of the shares subject to the option vesting on January 28, 2021 and the remaining shares vesting in equal monthly installmentsChou’s compensation for the 36 months thereafter, so long as Dr. Goldsmith continues to provide services to us on each applicable vesting date.years ended 2022 and 2023 are included above in the Summary Compensation Table.

Pursuant to the terms of his employment agreement, in the event Dr. GoldsmithChou is terminated without “cause” or resigns for “good reason” (as such terms are defined in his employment agreement), Dr. GoldsmithChou will, subject to his execution and non-revocation of a release of claims, be entitled to a lump-sum cash amount equal to (i) 12 months of his base salary, provided that such amount will be reduced to nine months’salary; (ii) 100% of his base salary if Dr. Goldsmith’s termination occurs prior to the completion of his first year of service on January 28, 2021; (ii) his annual target bonus for the year in which such termination occurs, pro-rated for a partial year of service;occurs; and (iii) the amount of COBRA premiums he would be required to pay to maintain group healthcare coverage as in effect on the date of his termination for 12 months. In addition, Dr. Goldsmith’s equity awards will accelerate and become exercisable, as applicable, with respect the number of shares that would have vested if Dr. Goldsmith had remained in service for an additional 24 months. Each of Dr. Goldsmith’s option awards, to the extent vested after giving effect to the foregoing sentence, will remain exercisable until the earliest to occur of the one-year anniversary following Dr. Goldsmith’s termination of service, and the original expiration date of such option.

In the event heDr. Chou is terminated without “cause” or resigns for “good reason” (as such terms are defined in his employment agreement), within two months prior to, or 12 months following, a “change in control” (as such term is defined in his employment agreement),control,” then in lieu of the foregoing and subject to his execution and non-revocation of a release of claims, Dr. GoldsmithChou would be entitled to a lump-sum cash amount equal to (i)18 months of his base salary;salary at that time; (ii) 1.5x150% his annual target bonus for the year in which such termination occurs; and (iii) the amount of COBRA premiums he would be required to pay to maintain group healthcare coverage as in effect on the date of his termination for 18 months. In addition, in the event that a successor company does not assume or substitute equity awards held by Dr. GoldsmithChou in connection with a “change in control”,control,” or Dr. GoldsmithChou experiences a qualifying termination as described above within two months prior to, or 12 months following a “change in control”control,” (as defined in his employment agreement), Dr. Goldsmith’sChou’s then-outstanding equity awards will become fully vested and exercisable, as applicable, and forfeiture restrictions thereon will lapse. Unless otherwise set forth in an applicable grant agreement, any performance conditions applicable to such equity awards will be deemed achieved at the greater of target or actual performance. Each of Dr. Goldsmith’s option awards, to the extent vested after giving effect to the foregoing sentence, will remain exercisable

26


until the earliest to occur of the one-year anniversary following Dr. Goldsmith’s termination of service, and the original expiration date of such option.

Each of the foregoing severance payments and benefits are subject to Dr. Goldsmith’sChou’s execution of a general release of claims against us, and his compliance with certain non-competition and non-solicitation provisions set forth in his employment agreement or our standard confidentiality and inventions assignment agreement. To the extent such severance payments and benefits are payable in connection with a change in control and would result in excise taxes imposed by Section 4999 of the Internal Revenue Code of 1986, as amended, then pursuant to this employment agreement, Dr. GoldsmithChou would be entitled to receive (i) the full payment of such payments and benefits or (ii) such lesser amount as would result in no portion of those payments and benefits being subject to the excise tax, whichever results in the greater net after-tax position for Dr. Goldsmith.Chou.

Edgar B. (Chip) Cale

On September 23, 2019, Edgar B. (Chip) Cale, was appointed as our General Counsel and in December 2019 as our Corporate Secretary. Effective as of the May 31, 2022, the Board of Directors also appointed Mr. Cale as Interim Chief Executive Officer and President, a role in which Mr. Cale served until October 10, 2022. Mr. Cale’s employment agreement provides for at-will employment and included his initial base salary, discretionary annual incentive bonus opportunity, certain initial equity incentive awards and standard employee benefit plan participation. The details of Mr. Cale’s compensation for the years ended 2023 and 2022 are included above in the Summary Compensation Table.

Pursuant to Ms. Quigley’sthe terms of his employment agreement, as amended, ifin the executive is terminated without “cause” or resigns for “good reason” (as such terms are defined in her employment agreement), she will be entitled to (i) a lump-sum payment equal to 12 months of her base salary, (ii) a taxable lump-sum payment equal to 12 months of COBRA premiums she would be required to pay to maintain group healthcare coverage as in effect on the date of termination, (iii) a pro-rata target bonus for the year in which the termination occurs and (iv) 12 months acceleration of any then-outstanding unvested equity awards.

Pursuant to Dr. Romano’s employment agreement, as amended, if prior to August 15, 2021, the executiveevent Mr. Cale is terminated without “cause” or resigns for “good reason” (as such terms are defined in his employment agreement), (i) heMr. Cale will, receive accelerated vestingsubject to his execution and non-revocation of stock options that are scheduleda release of claims, be entitled to vest in the 12 month period after his termination date, (ii) his post-termination exercise period for vested stock options as of August 15, 2021 will be extendeda lump-sum cash amount equal to 12 months after termination of employment, (iii) upon termination of employment, he will receive a lump sum payment equal to(i) 12 months of his annualbase salary plus a lump sum equal to twelve months(ii) the amount of the monthly COBRA premiumpremiums he would be required to pay to continuemaintain group healthcare coverage as in effect on the group health plan, payable within 30 days after the termination date and (iv) the terms of his non-competition agreement willtermination for 12 months.

In the event Mr. Cale is terminated without “cause” or resigns for “good reason” (as such terms are defined in his employment agreement), within two months prior to, or 12 months following, a “change in control,” then in lieu of the foregoing and subject to his execution and non-revocation of a release of claims, Mr. Cale would be revised.

entitled to a lump-sum cash amount equal to (i) 12 months of his base salary; (ii) 100% his annual target bonus for the year in which such termination occurs; and (iii) the amount of COBRA premiums he would be required to pay to maintain group healthcare coverage as in effect on the date of his termination for 12 months. In addition, in the event that a successor company does not assume or substitute the equity awards held by Ms. Quigley and Dr. RomanoMr. Cale in connection with a “change in control”,control,” or if the executive is terminated without “cause” or resigns for “good reason”Mr. Cale experiences a qualifying termination as described above within two months prior to, or 12 months following a “change in control” (as such terms are defined in their respectivehis employment agreements)agreement), then, his or her then outstanding unvested options and otherMr. Cale’s then-outstanding equity awards will become fully vested and exercisable, as applicable, and any forfeiture restrictions thereon will lapse and in addition to the severance noted above, and the executive will receive 100% of his or her then current target bonus, payable in a lump sum.lapse. Unless otherwise set forth in an applicable grant agreement, any performance conditions applicable to such equity awards will be deemed achieved at the greater of target or actual performance.

The

Each of the foregoing severance payments and benefits are subject to the Ms. Quigley’s and Dr. Romano’sMr. Cale’s execution of a general release of claims against us, and the executive’shis compliance with certain non-competition and non-solicitation provisions set forth in the executive’shis employment agreement or our standard confidentiality and inventions assignment agreement. To the extent such severance payments and benefits are payable in connection with a change in control and would result in excise taxes imposed by Section 4999 of the Internal Revenue Code of 1986, as amended, then pursuant to the executive’s respectivethis employment agreement, the executiveMr. Cale would be entitled to receive (i) the full payment of such payments and benefits or (ii) such lesser amount as would result in no portion of those payments and benefits being subject to the excise tax, whichever results in the greater net after-tax position for the executive.Mr. Cale.

29

27


Table

Mark Forman M.D., Ph.D.

On March 30, 2020, Mark Forman M.D, Ph.D., was appointed as our Chief Medical Officer. Dr. Forman’s employment agreement provides for at-will employment and included his initial base salary, discretionary annual incentive bonus opportunity, certain initial equity incentive awards and standard employee benefit plan participation. The details of ContentsDr. Forman’s compensation for the year ended 2023 are included above in the Summary Compensation Table.

Pursuant to the terms of his employment agreement, in the event Dr. Forman is terminated without “cause” or resigns for “good reason” (as such terms are defined in his employment agreement), Dr. Forman will, subject to his execution and non-revocation of a release of claims, be entitled to a lump-sum cash amount equal to (i) 12 months of his base salary and (ii) the amount of COBRA premiums he would be required to pay to maintain group healthcare coverage as in effect on the date of his termination for 12 months.

In the event Dr. Forman is terminated without “cause” or resigns for “good reason” (as such terms are defined in his employment agreement), within two months prior to, or 12 months following, a “change in control,” then in lieu of the foregoing and subject to his execution and non-revocation of a release of claims, Dr. Forman would be entitled to a lump-sum cash amount equal to (i) 12 months of his base salary; (ii) 100% his annual target bonus for the year in which such termination occurs; and (iii) the amount of COBRA premiums he would be required to pay to maintain group healthcare coverage as in effect on the date of his termination for 12 months. In addition, in the event that a successor company does not assume or substitute equity awards held by Dr. Forman in connection with a “change in control,” or Dr. Forman experiences a qualifying termination as described above within two months prior to, or 12 months following a “change in control” (as defined in his employment agreement), Dr. Forman’s then-outstanding equity awards will become fully vested and exercisable, as applicable, and forfeiture restrictions thereon will lapse. Unless otherwise set forth in an applicable grant agreement, any performance conditions applicable to such equity awards will be deemed achieved at the greater of target or actual performance.

Each of the foregoing severance payments and benefits are subject to Dr. Forman’s execution of a general release of claims against us, and his compliance with certain non-competition and non-solicitation provisions set forth in his employment agreement or our standard confidentiality and inventions assignment agreement. To the extent such severance payments and benefits are payable in connection with a change in control and would result in excise taxes imposed by Section 4999 of the Internal Revenue Code of 1986, as amended, then pursuant to this employment agreement, Dr. Forman would be entitled to receive (i) the full payment of such payments and benefits or (ii) such lesser amount as would result in no portion of those payments and benefits being subject to the excise tax, whichever results in the greater net after-tax position for Dr. Forman.

Alexandros Fotopoulos

Mr. Fotopoulos’s separation from the Company was effective as of July 28, 2023. Pursuant to the terms of his Transition and Separation Agreement, dated July 19, 2023 (the Fotopoulos Separation Agreement), Mr. Fotopoulos was provided with (i) a lump sum payment of $484,088, equal to his annual salary for 2023; (ii) a lump-sum payment of $200,000, equal to his retention bonus; (iii) a lump sum of $39,077, equal to 12 months of the monthly COBRA premium required to pay to continue his group health coverage; (iv) continued vesting in his then outstanding Company option awards through the Advisory Term (as defined below); and (v) provided the Advisory agreement is not terminated prior to July 28, 2024, full vesting acceleration in the Restricted Stock Units granted on May 17, 2021. In addition, the deadline to exercise the unexercised vested shares subject to the Stock Option Agreement that he entered into with the Company on January 28, 2020, and February 16, 2021 was extended to the 12-month anniversary of the last day of the Advisory Term. In exchange for these termination benefits, Mr. Fotopoulos executed a general release of claims against us and agreed to comply with certain non-competition and non-solicitation provisions set forth in the Transition and Separation Agreement and our standard confidentiality and inventions assignment agreement.

The Company engaged Mr. Fotopoulos as an advisor, with an effective start date of July 28, 2023, and until July 28, 2024 (the Advisory Term). Pursuant to the terms of his Advisory Agreement, dated July 19, 2023 (the Advisory Agreement), Mr. Fotopoulos was provided with a monthly advisory fee equal to $5,000 through the first six months of the Advisory Term and was paid based on an hourly rate thereafter.

The details of Mr. Fotopoulos’s compensation as an employee and as an advisor and the compensation paid in connection with the Fotopoulos Separation Agreement for the year ended 2023 are included above in the Summary Compensation Table. The details of Mr. Fotopoulos’s compensation for the year ended 2022 as an employee are also included above in the Summary Compensation Table.

30

Simona King

Ms. King’s separation from the Company was effective as of July 28, 2023. Pursuant to the terms of her Transition and Separation Agreement, dated July 19, 2023 (the King Separation Agreement), Ms. King was provided (i) a lump-sum payment of $466,650 equal to 12 months of her base salary in 2023; (ii) a lump-sum payment of $200,000, representing her retention bonus; (iii) a lump sum of $33,370.96, equal to 12 months of the monthly COBRA premium required to pay to continue her group health coverage; (iv) immediate vesting of 31,250 restricted stock units, equal to the pro rata amount of the grant dated November 10, 2022, (v) partial acceleration of the vesting of her options and (vi) an extension to her post-employment deadline to exercise any unexercised vested options to purchase shares of the Company’s common stock to the 12-month anniversary of July 28, 2023. In exchange for these termination benefits, Ms. King executed a general release of claims against us and agreed to comply with certain non-competition and non-solicitation provisions set forth in her separation agreement and our standard confidentiality and inventions assignment agreement.

The details of Ms. King’s compensation as an employee and compensation paid in connection with the King Separation Agreement for the year ended 2023 are included above in the Summary Compensation Table. The details of Ms. King’s compensation for the year ended 2022 as an employee are also included above in the Summary Compensation Table.

31

EQUITY COMPENSATION PLAN INFORMATION

The following table presents information as of December 31, 20202023, with respect to compensation plans under which shares of our common stock may be issued.

    

    

Weighted-

    

average

Number of securities

exercise price of

Number of securities

to be issued upon

outstanding

remaining available

exercise of

options,

for future issuance

outstanding options,

 

warrants and

under equity

Plan category

warrants and rights (1)

 

rights

compensation plans (2)

Equity compensation plans approved by security holders

 

6,928,111

$

12.36

 

3,320,729

Equity compensation plans not approved by security holders

 

 

 

Total

 

6,928,111

$

12.36

 

3,320,729


     Weighted-       
     average  Number of Securities  Number of securities 
  Number of securities  exercise price of  to be issued upon  remaining available 
  to be issued upon  outstanding  vesting and settlement  for future issuance 
  exercise of  options and  of outstanding restricted  under equity compensation 
Plan category outstanding options  rights  stock units  plans 
Equity compensation plans approved by security holders (1)  7,905,608(1)  $5.88   927,000   10,144,681(2) 
Equity compensation plans not approved by security holders  1,384,700(3)   4.21   0   1,110,300(4) 
Total  9,290,308  $5.63   927,000   11,254,981 

1)

(1)Includes outstanding awards under our 2018 Equity Incentive Plan (2018 EIP)EIP and our 2020 Equity Incentive Plan (2020 EIP).EIP. Excludes purchase rights accruing under our 2020 Employee Stock Purchase Plan (2020 ESPP).

2)(2)Represents (i) no shares available for future issuance under 2018 EIP, (ii) 8,666,526 shares available for issuance under our 2020 EIP, and (iii) 1,478,155 shares available for issuance under our 2020 ESPP. There are no shares of common stock available for issuance under our 2018 EIP, but the plan continues to govern the terms of stock options granted thereunder. Any shares of common stock that are subject to outstanding awards under the 2018 EIP that are issuable upon the exercise of stock options that expire or become unexercisable for any reason without having been exercised in full will generally be available for future grant and issuance under our 2020 EIP. In addition, the 2020 EIP provides for an automatic increase in the number of shares reserved for issuance thereunder on January 1 of each year for the remaining term of the plan equal to (a)(i) 5.0% of the number of issued and outstanding shares of common stock on December 31 of the immediately preceding year, or (b)(ii) an amount as approved by the boardBoard of Directors each year. Pursuant to this provision, the number of shares reserved for grant and issuance under our 2020 Plan increased by 2,295,845 shares2,747,206 on January 1, 2021.2024. Also, the 2020 Employee Stock Purchase PlanESPP provides for an automatic annual increase in the number of shares reserved for issuance thereunder on January 1 of each year for the remaining term of the plan equal to (a)(i) 1.0% of the number of issued and outstanding shares of common stock on December 31 of the immediately preceding year, or (2)(ii) a lesser amount as approved by the Board of Directors each year. Pursuant to this provision, the number of shares reserved for grant and issuance under our 2020 Employee Stock Purchase PlanESPP increased by 459,1700 shares on January 1, 2021.2024.

(3)Reflects outstanding options under our 2021 EIP.

(4)Reflects shares of common stock that remain available for grant under our 2021 EIP.

32

28


CERTAIN RELATIONSHIPS AND RELATED-PARTY TRANSACTIONS

Other than the executive officer and director compensation arrangements discussed above under “Executive Compensation” and “Proposal No. 1—Election of Directors-Director Compensation,” respectively, below we describe the transactions to which we were a party since

From January 1, 2019,2022 to the present, there have been no transactions, and there are currently no proposed transactions, in which the amount involved exceeded or will exceed the lesser of $120,000 and 1% of the average of the Company’s total assets at year-end for the prior two completed fiscal years and in which our directors, executive officers, former directors, former executive officers, director nominees and holders of more than 5% of our common stock, or other persons as may be required to be disclosed pursuant to Item 404 of Regulation S-K, had a direct or indirect material interest.interest, except for the executive officer and director compensation arrangements discussed above under the headings “Executive Compensation” and “Proposal No. 1 – Election of Class I Directors” respectively.

Sales of Convertible Preferred Stock

Series A-2

In May 2019, we sold an aggregate of 22,209,301 shares of our Series A-2 convertible preferred stock at a purchase price of $2.15 per share for an aggregate purchase price of approximately $47.7 million. Each 4.43316 shares of our Series A-2 convertible preferred stock automatically converted into one share of our common stock upon completion of our initial public offering. The following table summarizes the Series A-2 convertible preferred stock purchased by our executive officers, members, or former members, of our board of directors or their affiliates and holders of more than 5% of our outstanding capital stock:

    

Shares of

    

convertible

Total

 

preferred

 

purchase

Name of stockholder

 

stock

price ($)

Frazier Life Sciences IX, L.P.(1)

 

4,651,163

 

10,000,000

OrbiMed Private Investment VII, LP(2)

 

5,813,953

 

12,499,999

Versant Venture Capital VI, L.P.(3)

 

4,651,163

 

10,000,000

New Leaf Ventures III, L.P.(4)

 

2,325,581

 

4,999,999

Vivo Capital and affiliated entities(5)

 

2,325,581

 

4,999,999

LAV Prescience Limited(6)

 

2,325,581

 

4,999,999


1)Frazier Life Sciences IX, L.P., or Frazier, holds more than 5% of our outstanding capital stock. Patrick Heron, a member of board of directors whose term is expiring at our 2021 Annual Meeting, and Tadataka Yamada, M.D., a member of our board of directors, is the managing general partner and venture partner, respectively, at Frazier.
2)OrbiMed Private Investment VII, LP, or OrbiMed, holds more than 5% of our outstanding capital stock. Carl L. Gordon, Ph.D., CFA, and Stephen Squinto, Ph.D., each a former member of our board of directors, is the founding partner and venture partner, respectively, at OrbiMed.
3)These securities are held of record by Versant Venture Capital VI, L.P. (“VVC VI”). Versant Ventures VI GP, L.P. (“VV VI GP”) is the sole general partner of VVC VI. Versant Ventures VI GP-GP, LLC (“VV VI GP-GP”) is the sole general partner of VV VI GP and may be deemed to have voting and investment power over the securities held by VVC VI and as a result may be deemed to have beneficial ownership over such securities. Tom Woiwode, Ph.D., is a Managing Director of VV VI GP-GP and may be deemed to indirectly beneficially own the securities through his interest in VV VI GP-GP. Dr. Woiwode disclaims beneficial ownership of such securities, except to the extent of his pecuniary interest therein, if any.
4)New Leaf Ventures III, L.P., or New Leaf, previously held more than 5% of our outstanding capital stock. Liam Ratcliffe, M.D., Ph.D., a member of our board of directors, was previously a managing director at New Leaf.
5)Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. together previously held more than 5% of our outstanding capital stock.
6)LAV Prescience Limited holds more than 5% of our outstanding capital stock.

Series B

In August 2019, we sold an aggregate of 33,592,907 shares of our Series B convertible preferred stock at a purchase price of $3.2745 per share for an aggregate purchase price of approximately $110.0 million. Each 4.43316 shares of our Series B convertible preferred stock automatically converted into one share of our common stock upon completion of our initial public offering. The following table summarizes the Series B convertible preferred stock purchased by our

29


executive officers, members, or former members, of our board of directors or their affiliates and holders of more than 5% of our outstanding capital stock:

    

Shares of

    

convertible

Total

 

preferred

 

purchase

Name of stockholder

 

stock

price ($)

Frazier Life Sciences IX, L.P.(1)

 

1,918,681

 

6,282,721

OrbiMed and affiliated entities(2)

 

5,452,252

 

17,853,498

Versant Vantage I, L.P.(3)

 

3,140,241

 

10,282,719

New Leaf Ventures III, L.P.(4)

 

959,340

 

3,141,359

Vivo Capital and affiliated entities(5)

 

959,399

 

3,141,356

LAV Prescience Limited(6)

 

1,791,528

 

5,866,358

AI Passage LLC(7)

 

9,161,704

 

30,000,000


1)Frazier Life Sciences IX, L.P., or Frazier, holds more than 5% of our outstanding capital stock. Patrick Heron, a member of board of directors whose term is expiring at our 2021 Annual Meeting, and Tadataka Yamada, M.D., a member of our board of directors, is the managing general partner and venture partner, respectively, at Frazier.
2)Represents shares acquired by Worldwide Healthcare Trust PLC and OrbiMed Private Investment VII, LP, or OrbiMed. OrbiMed and Worldwide Healthcare Trust PLC are affiliated and collectively hold more than 5% of our outstanding capital stock. Carl L. Gordon, Ph.D., CFA, and Stephen Squinto, Ph.D., each a former member of our board of directors, is the founding partner and venture partner, respectively, at OrbiMed.
3)These securities are held of record by Versant Vantage I, L.P. (“VV I”). Versant Vantage I GP, L.P. (“VV I GP”) is the sole general partner of VV I. Versant Vantage I GP-GP, LLC (“VV I GP-GP”) is the sole general partner of VV I GP and may be deemed to have voting and investment power over the securities held by VV I and as a result may be deemed to have beneficial ownership over such securities. Tom Woiwode, Ph.D., is a Managing Director of VV I GP-GP and may be deemed to indirectly beneficially own the securities through his interest in VV I GP-GP. Dr. Woiwode disclaims beneficial ownership of such securities, except to the extent of his pecuniary interest therein, if any.
4)New Leaf Ventures III, L.P., or New Leaf, previously held more than 5% of our outstanding capital stock. Liam Ratcliffe, M.D., Ph.D., a member of our board of directors, was previously a managing director at New Leaf.
5)Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. together previously held more than 5% of our outstanding capital stock.
6)LAV Prescience Limited holds more than 5% of our outstanding capital stock.
7)AI Passage LLC, or Access, holds more than 5% of our outstanding capital stock. Liam Ratcliffe, M.D., Ph.D., a member of our board of directors, is affiliated with Access.

Insider Participation in Initial Public Offering

Certain of our principal stockholders and their affiliated entities, including stockholders affiliated with certain of our directors, purchased an aggregate of 3,233,900 shares of our common stock in our initial public offering on March 3, 2020 at the initial public offering price of $18.00 per share. The following table summarizes the shares of common stock purchased by our executive officers, members of our board of directors or their affiliates and holders of more than 5% of our outstanding capital stock in an amount exceeding $120,000:

    

Shares of

    

Total purchase

Name of stockholder

stock

price ($)

Frazier Life Sciences IX, L.P.(1)

 

550,000

 

9,900,000

OrbiMed and affiliated entities(2)

 

700,000

 

12,600,000

Versant Ventures and affiliated entities(3)

 

225,000

 

4,050,000

New Leaf Ventures and affiliated entities(4)

 

250,000

 

4,500,000

Vivo Capital and affiliated entities(5)

 

550,000

 

9,900,000

LAV Prescience Limited(6)

 

400,000

 

7,200,000

AI Passage LLC(7)

 

550,000

 

9,900,000

Athena Countouriotis

 

8,900

 

160,200


1)Frazier holds more than 5% of our outstanding capital stock. Patrick Heron, a member of board of directors whose term is expiring at our 2021 Annual Meeting, and Tadataka Yamada, M.D., a member of our board of directors, is the managing general partner and venture partner, respectively, at Frazier.

30


2)OrbiMed holds more than 5% of our outstanding capital stock. Stephen Squinto, Ph.D., a former member of our board of directors, is a venture partner at OrbiMed.
3)Versant Ventures holds more than 5% of our outstanding capital stock. Tom Woiwode, Ph.D., is a Managing Director of VV I GP-GP and may be deemed to indirectly beneficially own the securities through his interest in VV I GP-GP. Dr. Woiwode disclaims beneficial ownership of such securities, except to the extent of his pecuniary interest therein, if any.
4)New Leaf Ventures III, L.P., or New Leaf, previously held more than 5% of our outstanding capital stock. Liam Ratcliffe, M.D., Ph.D., a member of our board of directors, was previously a managing director at New Leaf.
5)Vivo Capital Fund VIII, L.P. and Vivo Capital Surplus Fund VIII, L.P. together previously held more than 5% of our outstanding capital stock.
6)LAV Prescience Limited holds more than 5% of our outstanding capital stock.
7)AI Passage LLC, or Access, holds more than 5% of our outstanding capital stock. Liam Ratcliffe, M.D., Ph.D., a member of our board of directors, is affiliated with Access.

Consulting Agreement

In January 2019, we entered into a consulting agreement with James M. Wilson, M.D., Ph.D., an employee at the University of Pennsylvania, to serve as our Chief Scientific Advisor, and at the time of entry into the consulting agreement a holder of greater than 5% of our outstanding capital stock. We will make payments of $100,000 per year for such consulting services, payable in quarterly installments at the beginning of each fiscal quarter. Additionally, we granted to Dr. Wilson a stock option to purchase 137,774 shares of our common stock at an exercise price of $1.02 per share. The consulting agreement automatically renewed on December 31, 2019 for an additional calendar year and was amended in January 2020 to provide that upon a termination of Dr. Wilson’s service resulting from a notice of non-renewal of the term of his consulting agreement or a termination by us, in either case other than for cause (as defined in the consulting agreement), death or disability within 2 months prior to, or 12 months following a change in control, then subject to Dr. Wilson’s execution and non-revocation of a release of claims in our favor, each of Dr. Wilson’s then-outstanding equity awards will accelerate and become fully vested upon such termination of service provided that, any equity awards subject to performance-based vesting conditions may be subject to alternative treatment pursuant to the applicable grant agreement and, absent any such treatment in the grant agreement, the vesting acceleration will be deemed achieved at the greater of target or actual performance.

Relationships with an Immediate Family Member of our Chief Operating Officer

In November 2018, we entered into a consulting agreement with Chris Quigley, the spouse of Jill Quigley, our Chief Operating Officer, to provide financial consulting services. In accordance with this agreement as compensation for services provided, we paid Mr. Quigley approximately $121,000 in 2019. In January 2020, we hired Mr. Quigley as Senior Director of Finance. He received a new hire option grant to purchase 36,567 shares of common stock at an exercise price of $11.00 and his base salary is less than $225,000, consistent with the compensation paid to employees in similar positions.

University of Pennsylvania

We are party to a license, research and collaboration agreement with Penn’s GTP, headed by Dr. Wilson. In accordance with this agreement we issued shares to Penn that caused them to become a holder of more than 5% of our outstanding common stock. Under our agreement with Penn we provide certain funding to Penn to conduct research and discovery work.

Loans to Executive Officers

In February 2019, we received a promissory note from Jill M. Quigley, J.D., our Chief Operating Officer, in connection with Ms. Quigley’s purchase of shares of our common stock. The principal amount of the note was $0.3 million, which accrued interest at 2.91%, compounding annually. The note was forgiven in full in January 2020.

In February 2019, we received a promissory note from Stephen Squinto, Ph.D., our former interim Chief Executive Officer, former Acting Head of Research and Development and a former director, in connection with Dr. Squinto’s

31


purchase of shares of our common stock. The principal amount of the note was $0.6 million, which accrued interest at 2.91%, compounding annually. The note was forgiven in full in January 2020.

Policies and Procedures for Related-Party Transactions

Our Board of Directors has adopted a written related person transactions policy. Under this policy, our executive officers, directors, nominees for election as a director, beneficial owners of more than 5% of our common stock, and any members of the immediate family of and any entity affiliated with any of the foregoing persons, are not permitted to enter into a material related person transaction with us without the review and approval of our audit committee,Audit Committee, or a committee composed solely of independent directors in the event it is inappropriate for our audit committeeAudit Committee to review such transaction due to a conflict of interest. The policy provides that any request for us to enter into a transaction with an executive officer, director, nominee for election as a director, beneficial owner of more than 5% of our common stock or with any of their immediate family members or affiliates in which the amount involved exceedsexceeded or will exceed the lesser of $120,000 and 1% of the average of the Company’s total assets at year-end for the prior two completed fiscal years will be presented to our audit committeeAudit Committee for review, consideration and approval. In approving or rejecting any such proposal, our audit committeeAudit Committee will consider the relevant facts and circumstances available and deemed relevant to the audit committee,Audit Committee, including, but not limited to, whether the transaction is on terms no less favorable than terms generally available to an unaffiliated third party under the same or similar circumstances and the extent of the related person’s interest in the transaction.

33

32


ADDITIONAL INFORMATION

Stockholder Proposals to be Presented at Next Annual Meeting

Requirements for Stockholder Proposals to be Brought Before an Annual Meeting. Our bylaws

The Bylaws provide that for stockholder nominations to our Board of Directors or other proposals to be considered at an annual meeting of stockholders, the stockholder must give timely notice thereof in writing to the Corporate Secretary at Passage Bio, Inc., One Commerce Square, 2005 Market Street, 39th Floor, Philadelphia, Pennsylvania 19103.

To be timely for our company’s annual meeting of stockholders to be held in 2022 (20222025 (2025 Annual Meeting), a stockholder’s notice must be delivered to or mailed and received by our Corporate Secretary at our principal executive offices not earlier than the close of business5:00 p.m. Eastern Time on January 27, 202221, 2025 and not later than the close of business5:00 p.m. Eastern Time on February 26, 2022.20, 2025. A stockholder’s notice to the Corporate Secretary must set forth as to each matter the stockholder proposes to bring before the 20222025 Annual Meeting the information required by applicable law and our bylaws.the Bylaws. However, if the date of the 20222025 Annual Meeting is more than 30 days before or more than 70 days after the one-year anniversary of the date of our 20212024 Annual Meeting, for the stockholder notice to be timely, it must be delivered to the Corporate Secretary at our principal executive offices not earlier than the close of business on the 120th day prior to the currently proposed annual meeting and not later than the close of business on the later of (1)(i) the 90th day prior to such annual meeting or (2)(ii) the close of business on the 10th day following the day on which public announcement of the date of such meeting is first made by us.

Requirements for Stockholder Proposals to be Considered for Inclusion in our Proxy Materials.

Stockholder proposals submitted pursuant to Rule 14a-8 under the Exchange Act and intended to be presented at our 20222025 Annual Meeting must be received by us not later than January 14, 2022December 10, 2024, in order to be considered for inclusion in our proxy materials for that meeting. A stockholder’s notice to the Corporate Secretary must set forth as to each matter the stockholder proposes to bring before the 20222025 Annual Meeting the information required by applicable law and our bylaws.the Bylaws.

Available Information

The Annual Report on Form 10-K is also available at https://investors.passagebio.com/financials-and-filings/sec-filings.sec-filings.

“Householding” – Stockholders Sharing the Same Address

The SEC has adopted rules that permit companies and intermediaries (such as brokers) to implement a delivery procedure called “householding.” Under this procedure, multiple stockholders who reside at the same address may receive a single copy of our Annual Report on Form 10-K and proxy materials, including the Notice of Internet Availability, unless the affected stockholder has provided other instructions. This procedure reduces printing costs and postage fees and helps protect the environment as well.

We expect that a number of brokers with account holders who are our stockholders will be “householding” our Annual Report on Form 10-K and proxy materials, including the Notice of Internet Availability. A single Notice of internet Availability and, if applicable, a single set of Annual Report on Form 10-K and other proxy materials will be delivered to multiple stockholders sharing an address unless contrary instructions have been received from one or more of the affected stockholders. Once you have received notice from your broker that it will be “householding” communications to your address, “householding” will continue until you are notified otherwise or until you revoke your consent. Stockholders may revoke their consent at any time by contacting their broker.

Upon written or oral request, we will undertake to promptly deliver a separate copy of the Notice of Internet Availability and, if applicable, proxy statement, proxy card, Annual Report on Form 10-K and other proxy materials to any stockholder at a shared address to which a single copy of any of those documents was delivered. To receive a separate copy of the Notice of Internet Availability and, if applicable, proxy statement, proxy card, Annual Report on Form 10-K and other proxy materials, you may write our Corporate Secretary at Passage Bio, Inc., One Commerce Square, 2005 Market Street, 39th Floor, Philadelphia, Pennsylvania 19103, Attn: Corporate Secretary, submit a request on our website at https://investors.passagebio.com/investor-resources/investor-contact or contact Edgar Cale at (267) 866-0311.

33


Any stockholders who share the same address and currently receive multiple copies of our Notice of Internet Availability or Annual Report on Form 10-K and other proxy materials who wish to receive only one copy in the future can contact their bank, broker or other holder of record to request information about “householding” or our Investor Relations Department at the address or telephone number listed above.

34

34


OTHER MATTERS

Our Board of Directors does not presently intend to bring any other business before the Annual Meeting and, so far as is known to the Board of Directors, no matters are to be brought before the Annual Meeting except as specified in the notice of the Annual Meeting. As to any business that may arise and properly come before the Annual Meeting, however, it is intended that proxies, in the form enclosed, will be voted in respect thereof in accordance with the judgment of the persons voting such proxies.

35


35

GraphicGRAPHIC

VOTE BY INTERNET Before The Meeting - Go to www.proxyvote.com Use the Internet to transmit your voting instructions and for electronic delivery of information up until 11:59 p.m. Eastern Time on May 26, 2021. Have your proxy card in hand when you access the web site and follow the instructions to obtain your records and to create an electronic voting instruction form. PASSAGE BIO, INC. ONE COMMERCE SQUARE 2005 MARKET STREET PHILADELPHIA, PA 19103 During The Meeting - Go to www.virtualshareholdermeeting.com/PASG2021 You may attend the meeting via the Internet and vote during the meeting. Have the information that is printed in the box marked by the arrow available and follow the instructions. VOTE BY PHONE - 1-800-690-6903 Use any touch-tone telephone to transmit your voting instructions up until 11:59 p.m. Eastern Time on May 26, 2021. Have your proxy card in hand when you call and then follow the instructions. VOTE BY MAIL Mark, sign and date your proxy card and return it as soon as possible before the Annual Meeting in the postage-paid envelope we have provided or return it to Vote Processing, c/o Broadridge, 51 Mercedes Way, Edgewood, NY 11717. TO VOTE, MARK BLOCKS BELOW IN BLUE OR BLACK INK AS FOLLOWS: D41921-P53897 KEEP THIS PORTION FOR YOUR RECORDS DETACH AND RETURN THIS PORTION ONLY THIS PROXY CARD IS VALID ONLY WHEN SIGNED AND DATED. PASSAGE BIO, INC. The Board of Directors recommends you vote FOR the following: For Withhold AllAll For AllTo withhold authority to vote for any individual Exceptnominee(s), mark "For All Except" and write the number(s) of the nominee(s) on the line below. ! ! ! 1. To elect three Class I directors, each to serve a three-year term through the third Annual Meeting of Stockholders following this meeting and until a successor has been elected and qualified or until earlier resignation or removal. Nominees: 01) Bruce A. Goldsmith, Ph.D. 02) Derrell D. Porter, M.D. 03) Tadataka Yamada, M.D. For Against Abstain The Board of Directors recommends you vote FOR the following proposal: ! ! ! 2. To ratify the appointment of KPMG LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2021. 3. Any such other business as may properly come before the meeting or any adjournment thereof. Please sign exactly as your name(s) appear(s) hereon. When signing as attorney, executor, administrator, or other fiduciary, please give full title as such. Joint owners should each sign personally. All holders must sign. If a corporation or partnership, please sign in full corporate or partnership name by authorized officer. Signature [PLEASE SIGN WITHIN BOX] Date Signature (Joint Owners) Date


GraphicGRAPHIC

Important Notice Regarding the Availability of Proxy Materials for the Annual Meeting: The Notice and Proxy Statement and 10K Wrap are available at www.proxyvote.com. D41922-P53897 PASSAGE BIO, INC. Annual Meeting of Stockholders May 27, 2021 4:30 PM This proxy is solicited by the Board of Directors The stockholder(s) hereby appoint(s) Bruce A. Goldsmith, Ph.D. and Richard S. Morris, as proxies, each with power to act without the other and each with the power to appoint his substitute, and hereby authorize(s) them to represent and to vote, as designated on the reverse side of this ballot, all of the shares of Common Stock of PASSAGE BIO, INC. that the stockholder(s) is/are entitled to vote at the Annual Meeting of Stockholders to be held at 4:30 PM, Easter n T ime on May 27, 2021, virtually at www.virtualshareholdermeeting.com/PASG2021, and any adjournment or postponement thereof. This proxy, when properly executed, will be voted in the manner directed herein. If no such direction is made, this proxy will be voted in accordance with the Board of Directors' recommendations. Continued and to be signed on reverse side